Evidence map›Paper›PMID 38658494›Full record

ArticleBiochemical genetics2025

Identification of Key lncRNAs Associated with Immune Infiltration and Prognosis in Gastric Cancer.

Wen Jin, Jianchao Jia, Yangming Si, Jianli Liu, Hanshuang Li, Hao Zhu, Zhouying Wu, Yongchun Zuo, Lan Yu

Abstract read
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In one paragraph

Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wen Jin *Clinical Medical Research Center, Inner Mongolia Key Laboratory of Gene Regulation of the Metabolic Disease, Inner Mongolia People's Hospital, Hohhot, 010010, China.
Jianchao Jia *Clinical Medical Research Center, Inner Mongolia Key Laboratory of Gene Regulation of the Metabolic Disease, Inner Mongolia People's Hospital, Hohhot, 010010, China.
Yangming SiLaboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot, 010021, China.
Jianli LiuSchool of Water Resource and Environment Engineering, China University of Geosciences, Beijing, 100083, China.
Hanshuang LiCollege of Life Sciences, Inner Mongolia University, Hohhot, 010070, China.
Hao ZhuClinical Medical Research Center, Inner Mongolia Key Laboratory of Gene Regulation of the Metabolic Disease, Inner Mongolia People's Hospital, Hohhot, 010010, China.
Zhouying WuClinical Medical Research Center, Inner Mongolia Key Laboratory of Gene Regulation of the Metabolic Disease, Inner Mongolia People's Hospital, Hohhot, 010010, China.
Yongchun ZuoCollege of Life Sciences, Inner Mongolia University, Hohhot, 010070, China. yczuo@imu.edu.cn.
Lan YuClinical Medical Research Center, Inner Mongolia Key Laboratory of Gene Regulation of the Metabolic Disease, Inner Mongolia People's Hospital, Hohhot, 010010, China. yulan@imph.ac.cn.
Inner Mongolia University · CNChina University of Geosciences (Beijing) · CN

Funding

National Natural Science Foundation of China 62061034National Natural Science Foundation of China 81960449Natural Science Foundation of Inner Mongolia 2022QN06007Science Research Foundation of Inner Mongolia People's Hospital 2021YN18
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs), as promising novel biomarkers for cancer treatment and prognosis, can function as tumor suppressors and oncogenes in the occurrence and development of many types of cancer, including gastric cancer (GC). However, little is known about the complex regulatory system of lncRNAs in GC. In this study, we systematically analyzed lncRNA and miRNA transcriptomic profiles of GC based on bioinformatics methods and experimental validation. An lncRNA-miRNA interaction network related to GC was constructed, and the nine crucial lncRNAs were identified. These 9 lncRNAs were found to be associated with the prognosis of GC patients by Cox proportional hazards regression analysis. Among them, the expression of lncRNA SNHG14 can affect the survival of GC patients as a potential prognostic marker. Moreover, it was shown that SNHG14 was involved in immune-related pathways and significantly correlated with immune cell infiltration in GC. Meanwhile, we found that SNHG14 affected immune function in many cancers, such as breast cancer and esophageal carcinoma. Such information revealed that SNHG14 may serve as a potential target for cancer immunotherapy. As well, our study could provide practical and theoretical guiding significance for clinical application of non-coding RNAs.

Indexed as

Gene Expression ProfilingMicroRNAsRNA, Long NoncodingStomach NeoplasmsCell Line, TumorGene Regulatory NetworksHumansPrognosisSurvival AnalysisMicroRNAsRNA, Long NoncodingSNHG14 lncRNA, humanGastric cancerImmune infiltrationLncRNA-miRNA regulatory networkLong non-coding RNAPrognosis

Identifiers

PMID38658494
OpenAlexW4395115493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.