Evidence map›Paper›PMID 38658453›Full record

Observational studyJapanese journal of ophthalmology2024

Real-life experience on the effectiveness of conjunctival flap and amniotic membrane graft in the treatment of refractory fungal corneal ulcer.

Khadiza Mahmuda, Moshahid Thakur, Paritush Kanti Talukdar, Tawfique Enayeth Tanim, Md Kamrul Islam Chowdury, Shamima Shanta, Mst Sabiha Afroz, Md Abdullah Saeed Khan, Mohammad Jahid Hasan

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Khadiza MahmudaDepartment of Ophthalmology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh.
Moshahid ThakurDepartment of Ophthalmology, Jalalabad Ragib Rabeya Medical College, Sylhet, Bangladesh.
Paritush Kanti TalukdarDepartment of Ophthalmology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh.
Tawfique Enayeth TanimDepartment of Ophthalmology, Jalalabad Ragib Rabeya Medical College, Sylhet, Bangladesh.
Md Kamrul Islam ChowduryDepartment of Ophthalmology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh.
Shamima ShantaOSD, DGHS, National Institute of Ophthalmology, Dhaka, Bangladesh.
Mst Sabiha AfrozDepartment of Ophthalmology, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh.
Md Abdullah Saeed KhanPi Research and Development Center, Dhaka, Bangladesh.
Mohammad Jahid HasanPi Research and Development Center, Dhaka, Bangladesh. dr.jahid61@gmail.com.
Sylhet MAG Osmani Medical College · BDBangladesh Institute of Development Studies · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate and compare the results of the conjunctival flap (CF) and cryopreserved amniotic membrane graft (AMG) in the management of fungal corneal ulcers either with complications or non-responsive to medical treatment. STUDY

designA retrospective observational study.

methodsMedical records of 30 patients with culture-positive fungal corneal ulcer treated with either CF or AMG (15 eyes in each group) in real world settings were retrieved for analysis. After the surgical procedure, patients were followed up on days 1, 7, 14, 21, 30, 60, 90, 120, and 180 to explore the outcomes of the operations along with complications.

resultsInfecting fungi were of genus Fusarium (n = 11), Aspergillus (n = 10), Mucor (n = 4) and Penicillium (n = 10). The most common indication was resistant ulcer with perforation. After the procedure, epithelization was completed in 11(73.33%) patients in the CF, and 13 patients in the (86.67%) AMG group. Visual acuity improvement was significantly better in the latter group (CF: 1 [6.67%] vs. AMG: 7 [46.67%], p = 0.023). Flap failure occurred in 4 patients (26.67%) from the CF and 2 (13.33%) from the AMG group. No significant differences were found between the two groups regarding success rate (p = 0.651), epithelialization time (p = 0.691), healing of corneal ulcer (p = 0.651), and postoperative stability (p = 0.651) of the flaps.

conclusionsCF and AMG are both effective for the management of refractory fungal corneal ulcers. However, AMG appears to improve visual acuity better than CF.

Indexed as

AmnionConjunctivaCorneal UlcerEye Infections, FungalSurgical FlapsVisual AcuityAdultAgedFemaleFollow-Up StudiesFungiHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAmniotic membrane graftConjunctival flapCorneaFungal corneal ulcerRefractory corneal ulcer

Identifiers

PMID38658453
OpenAlexW4395462720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.