Evidence map›Paper›PMID 38658324›Full record

ArticlePhysiological reports2024

Right ventricular preload and afterload challenge induces contractile dysfunction and arrhythmia in isolated hearts of dystrophin-deficient male mice.

Andrew Behrmann, Jessica Cayton, Matthew R Hayden, Michelle D Lambert, Zahra Nourian, Keith Nyanyo, Brooke Godbee, Laurin M Hanft, Maike Krenz, Kerry S McDonald and 1 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Andrew BehrmannMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Jessica CaytonDepartment of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA.
Matthew R HaydenMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0002-9680-6644
Michelle D LambertMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Zahra NourianMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Keith NyanyoMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Brooke GodbeeMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.ORCID 0009-0000-9066-9899
Laurin M HanftMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Maike KrenzMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Kerry S McDonaldMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.
Timothy L DomeierMedical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0003-0340-6551
University of Missouri · US

Funding

Cardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5M
NHLBI NIH HHS R01 HL136292
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and elevated afterload on the right ventricle (RV). Thus, RV dysfunction in DMD develops early in disease progression. Herein, we deliver a 30-min sustained RV preload/afterload challenge to isolated hearts of wild-type (Wt) and dystrophic (Dmd

Indexed as

Arrhythmias, CardiacDystrophinMyocardial ContractionAnimalsMaleMiceMice, Inbred C57BLMice, Inbred mdxMuscular Dystrophy, DuchenneVentricular Dysfunction, RightDystrophincardiac arrhythmiamdx mouse modelmuscular dystrophypulmonary hypertensionright ventricleventricular tachycardia

Identifiers

PMID38658324
PMCPMC11043033
OpenAlexW4395466036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.