Evidence map›Paper›PMID 38657342›Full record

ArticlePsychoneuroendocrinology2024

Higher prenatal anxiety predicts lower neonatal hair cortisol.

LillyBelle K Deer, Ella-Marie P Hennessey, Jenalee R Doom, Robert J Gallop, M Camille Hoffman, Catherine H Demers, Benjamin L Hankin, Elysia Poggi Davis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

LillyBelle K DeerDepartment of Psychology, University of Denver, Denver, CO, USA. Electronic address: lillybelle.deer@du.edu.
Ella-Marie P HennesseyDepartment of Psychology, University of Denver, Denver, CO, USA.
Jenalee R DoomDepartment of Psychology, University of Denver, Denver, CO, USA.
Robert J GallopDepartment of Mathematics, West Chester University, West Chester, PA, USA.
M Camille HoffmanDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, CO, USA.
Catherine H DemersDepartment of Psychology, University of Denver, Denver, CO, USA; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Benjamin L HankinDepartment of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Elysia Poggi DavisDepartment of Psychology, University of Denver, Denver, CO, USA; Department of Pediatrics, University of California, Irvine, Irvine, CA, USA.
University of Denver · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Illinois Urbana-Champaign · USWest Chester University · US

Funding

Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk MechanismsR01MH109662 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2017 to 2021
$4.0M
Reducing maternal prenatal depression to improve child cardiovascular healthR01HL155744 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, DOOM, JENALEE RAE · 2021 to 2025
$3.6M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular healthK01HL143159 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DOOM, JENALEE RAE · 2019 to 2023
$788k
Placental CRH and child cardiovascular disease risk and obesogenic eating behaviorsF32HL165844 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEER, LILLYBELLE KUULEI · 2022 to 2024
$165k
Prenatal maternal depression exposure and infant neurocircuitry developmentF32MH125572 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEMERS, CATHERINE · 2021 to 2021
$66k
NHLBI NIH HHS F32 HL165844NHLBI NIH HHS K01 HL143159NHLBI NIH HHS R01 HL155744NIAMS NIH HHS K12 AR084226NIMH NIH HHS F32 MH125572NIMH NIH HHS R01 MH109662
6 · The paper itself

Abstract

backgroundPrenatal glucocorticoids are one of the most widely proposed prenatal programming mechanisms, yet few studies exist that measure fetal cortisol via neonatal hair. Neonatal hair provides a window into the fetal experience and represents cortisol accumulation in the third trimester of pregnancy. In the current study, we test the links between two types of anxiety over the course of gestation (pregnancy-related anxiety and general anxiety) with neonatal hair cortisol.

methodPregnant individuals (N = 107) and their neonates (59.8% female) participated in the current study. Prenatal pregnancy-related anxiety and general anxiety were measured using the Pregnancy Related Anxiety Scale (PRAS) and the State-Trait Anxiety Inventory (STAI), in each trimester of pregnancy. Hierarchical linear modeling was used to model the intercept and slope of each type of anxiety over gestation. Neonatal hair samples were collected shortly after birth (Median

resultsBoth higher pregnancy-related anxiety and general anxiety at the beginning of pregnancy and a flatter decline of pregnancy-related anxiety over gestation were associated with lower neonatal hair cortisol. After inclusion of gestational age at birth and parity as covariates, pregnancy-related anxiety (intercept: β = -0.614, p =.012; slope: β = -0.681, p =.006), but not general anxiety (intercept: β = -0.389, p =.114; slope: β = -0.302, p =.217) remained a significant predictor. Further, when both general and pregnancy-related anxiety were entered into the same model, only pregnancy-related anxiety (intercept and slope) were significant predictors of neonatal hair cortisol, indicating an association with pregnancy-related anxiety above and beyond general anxiety.

conclusionCortisol plays a central role in maturation of fetal organ systems, and at the end of gestation, higher cortisol has beneficial effects such as promoting fetal lung maturation. Further, lower maternal cortisol is linked to less optimal cognitive development and altered brain development. As maternal higher anxiety in early pregnancy and a flatter decrease over time are both associated with lower neonatal hair cortisol, maternal pregnancy-related anxiety could be a target of future intervention efforts.

Indexed as

AnxietyHairHydrocortisoneAdultFemaleGestational AgeHumansInfant, NewbornMalePregnancyPregnancy ComplicationsPregnancy Trimester, ThirdHydrocortisoneDOHaD hypothesisGeneral anxietyHair cortisolHPA axisNeonatePregnancy-related anxiety

Identifiers

PMID38657342
PMCPMC11139573
OpenAlexW4394010027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.