Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Youngbin TchoeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-7807-5318
Tianhai WuIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Hoi Sang UIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
David M RothIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.
Dongwoo KimIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-2514-724X
Jihwan LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1971-0152
Daniel R ClearyIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-7112-4519
Patricia PizarroIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0009-0009-6327-917X
Karen J TonsfeldtIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8044-8857
Keundong LeeIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5880-2434
Po Chun ChenIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0190-6432
Andrew M BourhisIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-4927-4374
Ian GaltonDepartment of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9145-0055
Brian CoughlinDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-8009-5614
Jimmy C YangDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-1995-5926
Angelique C PaulkDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4413-3417
Eric HalgrenDepartment of Neurological Surgery, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5926-6872
Sydney S CashDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-4557-6391
Shadi A DayehIntegrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1756-1774
Funding
Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of EpilepsyUG3NS123723 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2025
$9.5M
Integrated Biophysical and Neural Model of Electrical Stimulation EffectsR01NS109553 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAZHENOV, MAKSIM V, HALGREN, ERIC · 2019 to 2023
$4.4M
Bringing Light to Functional Mapping in Resective NeurosurgeryDP2EB029757 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2019 to 2019
$2.4M
Integration of High Definition Display Technologies with Platinum Nanorod Microelectrodes for Large Scale in-vivo Recording and StimulationR01NS123655 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAYEH, SHADI · 2021 to 2021
$2.0M
Functional Mapping of the Suprachiasmatic NucleusK99NS119291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TONSFELDT, KAREN JILL · 2022 to 2023
Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which can be time-consuming. In addition, the electrode grids that are used to measure brain activity and to identify the boundaries of pathological versus functional brain regions have low resolution and limited conformity to the brain surface. Here, we present the development of an intracranial electroencephalogram (iEEG)-microdisplay that consists of freestanding arrays of 2048 GaN light-emitting diodes laminated on the back of micro-electrocorticography electrode grids. With a series of proof-of-concept experiments in rats and pigs, we demonstrate that these iEEG-microdisplays allowed us to perform real-time iEEG recordings and display cortical activities by spatially corresponding light patterns on the surface of the brain in the surgical field. Furthermore, iEEG-microdisplays allowed us to identify and display cortical landmarks and pathological activities from rat and pig models. Using a dual-color iEEG-microdisplay, we demonstrated coregistration of the functional cortical boundaries with one color and displayed the evolution of electrical potentials associated with epileptiform activity with another color. The iEEG-microdisplay holds promise to facilitate monitoring of pathological brain activity in clinical settings.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
An electroencephalogram microdisplay to visualize neuronal activity on the brain surface. · full record | OpenQuestion