Evidence map›Paper›PMID 38656622›Full record

ArticleJournal of neurology2024

GBA moderates cognitive reserve's effect on cognitive function in patients with Parkinson's disease.

Chia-Wen Chang, Chun-Hsiang Tan, Wei-Pin Hong, Rwei-Ling Yu

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Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Updates on Parkinson's Disease.Neuropsychiatric disease and treatment · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chia-Wen Chang *Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0009-0001-9595-8320
Chun-Hsiang Tan *Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID http://orcid.org/0000-0001-6950-4678
Wei-Pin HongDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Rwei-Ling YuInstitute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. lingyu@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0001-5836-1237

Funding

Ministry of Science and Technology 110-2628-B-006-020Ministry of Science and Technology 111-2628-B-006-020National Cheng Kung University Hospital 11210045National Science and Technology Council 112-2628-B-006-002
6 · The paper itself

Abstract

backgroundCognitive reserve (CR) involves an individual's ability to maintain cognitive vitality over their lifespan. Glucocerebrosidase (GBA) gene mutations contribute to additional effects on cognitive function in Parkinson's disease (PD) patients, but the interplay between GBA mutations and CR remains unclear. We investigated the interactions among CR, GBA, and diseases, aiming to examine whether the CR established at different stages interacts with specific genotypes to affect cognitive function.

methodsThree hundred and eighteen participants' CR indicators (i.e., education, occupation, and social function) and comprehensive neuropsychological function (i.e., tests for executive function, attention/working memory, visuospatial function, memory, and language) were evaluated.

resultsWe found that CR established in a specific life stage influences the individual's cognitive function, particularly in PD, based on their distinct GBA rs9628662 genotypes. Attention/working memory and memory performance are affected by occupational complexity in midlife in PD patients with the GG genotype (q < 0.0001; q < 0.0001) and healthy adults with the T genotype (q = 0.0440; q < 0.0001). Language is influenced by early education and occupation, and the effects of occupation are also observed in PD patients with the GG genotype (q = 0.0040) and in healthy adults carrying the T genotype (q = 0.0040).

conclusionsCR, established at different life stages, can be influenced by the GBA rs9628662 genotype, impacting later-life cognition. Validating genotypes and incorporating genotype information when assessing cognitive reserve effects is crucial and can enhance targeted cognitive training.

Indexed as

Cognitive ReserveGlucosylceramidaseParkinson DiseaseAdultAgedCognitionCognitive DysfunctionExecutive FunctionFemaleGenotypeHumansMaleMiddle AgedNeuropsychological TestsGBA protein, humanGlucosylceramidaseCognitive ReserveGBA mutationsHealthcareNeuropsychological functionParkinson's Disease

Identifiers

PMID38656622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.