ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2024
The effects of gender-affirming hormone therapy and mastectomy on psychopathology, body image, and quality of life in adults with gender dysphoria who were assigned female at birth.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Psychometric Evaluation and Clinical Norms of a Dutch Version of the Body Uneasiness Test Among Individuals With Self-Reported Eating Disorder Pathology.Journal of clinical psychology · 2026Article
- Early and Late Surgical Complications After Gender-affirming Mastectomy in Predominantly Young Adults: A Single-center Cohort Study.Plastic and reconstructive surgery. Global open · 2026Article
- Patient-reported outcomes following chest masculinization surgery in transmasculine individuals: A prospective study.JPRAS open · 2026Article
- Gender-Affirming Mastectomy in a Private Plastic Surgery Clinic in Poland: Sociodemographic Insights from a Cohort of 100 Transgender Individuals: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIndividuals with gender dysphoria (GD) may request hormone therapy and various surgical operations to change their physical characteristics. The present study aimed to investigate the effects of two treatments, mastectomy and gender-affirming hormone therapy (GAHT), on adults with GD who were assigned female at birth (GD AFAB).
methodsIn this cross-sectional study, we gathered data from a total of 269 individuals in three groups: (a) untreated group (n = 121), (b) GAHT group (n = 84) who had been receiving treatment for at least 6 months, and (c) GAHT-MAST group (n = 64) who had been using GAHT for at least 6 months and had undergone mastectomy at least 3 months prior. All participants were asked to complete the Symptom Checklist-90-Revised (SCL-90-R), the Body Uneasiness Test (BUT), and the World Health Organization's Quality of Life Questionnaire- Brief Form, Turkish Version (WHOQOL-BREF-Tr).
resultsWe found that individuals in the untreated group had higher psychopathological symptoms and body uneasiness scores, and lower quality of life scores compared to both GAHT and GAHT-MAST groups. There was no difference in psychopathology between the GAHT-MAST group and the GAHT group, but body uneasiness scores were lower, and quality of life scores were higher in the GAHT-MAST group.
conclusionOur study suggests that individuals receiving GAHT improved mental health, body satisfaction, and overall quality of life. Combining mastectomy with GAHT may further enhance these benefits.
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