Evidence map›Paper›PMID 38656316›Full record

ArticleBiomaterials science2024

Engineered coiled-coil HIF1α protein domain mimic.

Dustin Britton, Olga Katsara, Orin Mishkit, Andrew Wang, Neelam Pandya, Chengliang Liu, Heather Mao, Jakub Legocki, Sihan Jia, Yingxin Xiao and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Dustin BrittonDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Olga KatsaraDepartment of Microbiology, New York University School of Medicine, New York, New York, 10016, USA.
Orin MishkitCenter for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.
Andrew WangDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Neelam PandyaCenter for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.
Chengliang LiuDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Heather MaoDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Jakub LegockiDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Sihan JiaDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Yingxin XiaoDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Orlando AristizabalCenter for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.
Deven PaulDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.
Yan DengMicroscopy Laboratory, New York University Langone Health, New York, NY, 10016, USA.
Robert SchneiderDepartment of Microbiology, New York University School of Medicine, New York, New York, 10016, USA.
Youssef Z WadghiriCenter for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, New York, 10016, USA.
Jin Kim MontclareDepartment of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York, 11201, USA. montclare@nyu.edu.ORCID http://orcid.org/0000-0001-6857-3591
New York University · USAdvanced Imaging Research (United States) · USNYU Langone Health · USState University of New York · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Daniel K Sodickson · 2014 to 2026
$19.3M
7T Small Animal MRI Scanner Replacement for Translational Imaging ResourceS10OD018337 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BOADA, FERNANDO E · 2014 to 2014
$2.0M
NCI NIH HHS P30 CA016087NIBIB NIH HHS P41 EB017183NIH HHS S10 OD018337
6 · The paper itself

Abstract

The development of targeted anti-cancer therapeutics offers the potential for increased efficacy of drugs and diagnostics. Utilizing modalities agnostic to tumor type, such as the hypoxic tumor microenvironment (TME), may assist in the development of universal tumor targeting agents. The hypoxia-inducible factor (HIF), in particular HIF1, plays a key role in tumor adaptation to hypoxia, and inhibiting its interaction with p300 has been shown to provide therapeutic potential. Using a multivalent assembled protein (MAP) approach based on the self-assembly of the cartilage oligomeric matrix protein coiled-coil (COMPcc) domain fused to the critical residues of the C-terminal transactivation domain (C-TAD) of the α subunit of HIF1 (HIF1α), we generate HIF1α-MAP (H-MAP). The resulting H-MAP demonstrates picomolar binding affinity to p300, the ability to downregulate hypoxia-inducible genes, and

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitProtein EngineeringAnimalsCartilage Oligomeric Matrix ProteinCell Line, TumorE1A-Associated p300 ProteinHumansMiceProtein DomainsTumor MicroenvironmentCartilage Oligomeric Matrix ProteinE1A-Associated p300 ProteinHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID38656316
PMCPMC11191652
OpenAlexW4395096228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.