Evidence map›Paper›PMID 38656136›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Andexanet Alfa Neutralizes the Anticoagulant Effects of Unfractionated Heparin of Bovine, Ovine and Porcine Origin Almost as Protamine Sulfate.

Fakiha Siddiqui, Debra Hoppensteadt, Walter Jeske, Eduardo Ramacciotti, Alfonso Tafur, Jawed Fareed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Fakiha SiddiquiCardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.ORCID 0000-0002-2219-7049
Debra HoppensteadtCardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.ORCID 0000-0001-9342-4213
Walter JeskeCardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
Eduardo RamacciottiCardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.ORCID 0000-0002-5735-1333
Alfonso TafurNorthshore Cardiovascular Institute, NorthShore University Health Systems, Evanston, IL, USA.
Jawed FareedCardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.ORCID 0000-0003-3465-2499
Loyola University Chicago · USNorthShore University HealthSystem · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAndexanet alfa (AA) - zhzo, recombinant coagulation factor Xa, is an approved antidote for oral Xa inhibitors (apixaban and rivaroxaban). Unfractionated heparin (UFH) is commonly used for therapeutic, interventional, and surgical indications. Protamine sulfate (PrSO MATERIALS AND

methodsThe neutralization effect of PrSO

resultsIn the whole blood ACT studies, all three heparins produced strong anti-coagulant effects (400-450 seconds) compared to saline (130-150 seconds). Both AA and PrSO

conclusionAndexanet alfa at 100 µg/ml effectively neutralizes the therapeutic and surgical/interventional concentrations of heparins in

Indexed as

Factor XaHeparinHeparin AntagonistsProtaminesRecombinant ProteinsAnimalsAnticoagulantsBlood CoagulationCattleSheepSwineThrombin TimeAnticoagulantsFactor XaHeparinHeparin AntagonistsProtaminesPRT064445Recombinant Proteinsandexanet alfachromogenic assaysclot-based assaysheparinprotamine sulfatethrombin generation assay

Identifiers

PMID38656136
PMCPMC11044804
OpenAlexW4395096069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.