ArticlePolish archives of internal medicine2024
Molecular epidemiology and clinical significance of carbapenemase genes in carbapenem-resistant Acinetobacter baumannii isolates in southern Poland.
Article in Polish archives of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Multicenter outbreak of plasmid-encodedAntimicrobial agents and chemotherapy · 2026Article
- Epidemiology of Carbapenem-ResistantJournal of clinical medicine · 2026Article
- Genotyping of Acinetobacter baumannii clinical isolates from Polish hospitals uncovers novel sequence types.Scientific reports · 2025Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionA complex interplay between Acinetobacter spp., patients, and the environment has made it increasingly difficult to optimally treat patients infected with Acinetobacter spp., mainly due to rising antimicrobial resistance and challenges with surveillance.
objectivesThis study evaluated carbapenem‑resistant A. baumannii (CRAB) isolates to determine their resistance profiles and the presence of specific β‑lactamases to inform CRAB surveillance upon hospital admission and regional empiric antibiotic therapies. PATIENTS AND
methodsThe study was conducted at 4 hospitals in southern Poland between June and December 2022. Only health care-associated infections caused by A. baumannii were considered. A total of 82 CRAB isolates were included in the analysis. Species identification was performed by matrix‑assisted laser desorption / ionization time‑of‑flight mass spectrometry, antimicrobial susceptibility was determined phenotypically, and polymerase chain reactions were carried out to identify the resistance genes.
resultsDepending on the hospital, the incidence of CRAB infections varied from 428.6 to 759.5 per 10 000 admissions in intensive care units (ICUs), and from 0.3 to 21 per 10 000 admissions in non‑ICUs. CRAB antibiotic susceptibility was the highest for cefiderocol (100%), colistin (96%), tigecycline (77%), gentamicin (51%), and ampicillin / sulbactam (36%). The most prevalent blaOXA genes were blaOXA‑66‑1 (95%) and blaOXA‑40 (71%), and additionally the extended‑spectrum β‑lactamase gene blaTEM‑1 (41%).
conclusionAn unexpectedly high incidence of CRAB infections occurred in Polish hospitals. There is a need for effective CRAB prevention and control that includes effective hospital screening, national surveillance, and improved treatment options.
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