Evidence map›Paper›PMID 38655849›Full record

ArticleeLife2024

PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.

Marcel Proske, Robert Janowski, Sabrina Bacher, Hyun-Seo Kang, Thomas Monecke, Tony Koehler, Saskia Hutten, Jana Tretter, Anna Crois, Lena Molitor and 7 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. InheritedNeurology. Genetics · 2024
    Article
  5. Genes · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Marcel Proske *Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Robert Janowski *Institute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.ORCID https://orcid.org/0000-0002-9940-2143
Sabrina BacherInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Hyun-Seo KangInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Thomas MoneckeInstitute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany.ORCID https://orcid.org/0000-0003-3748-710X
Tony KoehlerInstitute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany.
Saskia HuttenBiocenter, Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.
Jana TretterInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Anna CroisInstitute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany.ORCID https://orcid.org/0009-0001-0791-5719
Lena MolitorInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Alejandro Varela-RialAcellera Labs SL, Barcelona, Spain.
Roberto FinoAcellera Labs SL, Barcelona, Spain.
Elisa DonatiAcellera Labs SL, Barcelona, Spain.
Gianni De FabritiisAcellera Labs SL, Barcelona, Spain.
Dorothee DormannBiocenter, Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.
Michael SattlerInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
Dierk NiessingInstitute of Structural Biology, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.ORCID https://orcid.org/0000-0002-5589-369X
Universität Ulm · DEAcellera (Spain) · ESTarget (Germany) · DECenter for Integrated Protein Science Munich · DEInstitute of Molecular Biology · BG

Funding

Deutsche Forschungsgemeinschaft Ni-1110/6-2
6 · The paper itself

Abstract

Mutations in the human

Indexed as

Neurodevelopmental DisordersProcessing BodiesAmino Acid SubstitutionCircular DichroismCrystallography, X-RayDimerizationDNA-Binding ProteinsHeLa CellsHumansPenetrancePoint MutationProtein DomainsProtein FoldingRecombinant ProteinsStress GranulesTranscription FactorsDNA-Binding ProteinsPURA protein, humanRecombinant ProteinsTranscription Factorscell biologyhumanmolecular biophysicsprotein folding stabilityPURAPURA syndromeRNA bindingstructural biologyX-ray crystallography

Identifiers

PMID38655849
PMCPMC11042805
OpenAlexW4391167431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.