Evidence map›Paper›PMID 38655660›Full record

ArticleCancer science2024

Microwave ablation combined with PD-L1 blockade synergistically promotes Cxcl9-mediated antitumor immunity.

Ningning He, Hao Huang, Shaoxian Wu, Weipeng Ji, Yicheng Tai, Ruicheng Gao, Yingting Liu, Yungang Liu, Lujun Chen, Dawei Zhu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Cxcl9 as a Marker of Adipose Tissue Changes Caused by Bariatric Surgery and Psoriasis.Clinical, cosmetic and investigational dermatology · 2026
    Article
  4. Review
  5. Preclinical study of TLR stimulation combined PD-1 antibody enhance the therapeutic effect of microwave ablation on NSCLC.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. SubvertingBiology · 2024
    Review
  10. Article
  11. CD8Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ningning HeCollege of Medicine, Yangzhou University, Yangzhou, China.ORCID https://orcid.org/0009-0006-3638-7800
Hao HuangDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Shaoxian WuDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Weipeng JiDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Yicheng TaiDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Ruicheng GaoDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Yingting LiuDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Yungang LiuDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Lujun ChenDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Dawei ZhuDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Xiao ZhengDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Jingting JiangCollege of Medicine, Yangzhou University, Yangzhou, China.ORCID https://orcid.org/0000-0002-3128-9762
Soochow University · CNJiangsu University · CN

Funding

Key R&D Project of Science and Technology Department of Jiangsu Province BE2022721National Natural Science Foundation of China 32270955National Natural Science Foundation of China 82202994National Natural Science Foundation of China 82303164Natural Science Foundation of Jiangsu Province BK20211065Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX23_2031The Science and Technology Support Plan (Social Development Project) of Changzhou CE20235058
6 · The paper itself

Abstract

Although microwave ablation (MWA) is an important curative therapy in colorectal cancer liver metastasis, recurrence still occurs clinically. Our previous studies have shown that the expression of programmed cell death 1 ligand 1 (PD-L1) is upregulated following MWA, suggesting that MWA combined with anti-PD-L1 treatment can serve as a promising clinical therapeutic strategy against cancer. Using MWA-treated preclinical mice models, MWA combined with αPD-L1 treatment decreased tumor growth and prolonged overall survival (OS). Furthermore, through flow cytometry and single-cell RNA sequencing analysis, we determined that the MWA plus αPD-L1 therapy significantly suppressed CD8

Indexed as

B7-H1 AntigenCD8-Positive T-LymphocytesChemokine CXCL9Immune Checkpoint InhibitorsMicrowavesAnimalsCell Line, TumorColorectal NeoplasmsCombined Modality TherapyFemaleHumansInterferon-gammaMiceMice, Inbred C57BLSignal TransductionSTAT1 Transcription FactorB7-H1 AntigenCd274 protein, mouseChemokine CXCL9Cxcl9 protein, mouseImmune Checkpoint InhibitorsInterferon-gammaSTAT1 Transcription FactorCxcl9immunotherapyIRF8microwave ablationPD‐L1

Identifiers

PMID38655660
PMCPMC11247550
OpenAlexW4395076675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.