Evidence map›Paper›PMID 38655616›Full record

ArticleActa biochimica et biophysica Sinica2024

Construction and efficacy testing of DNA vaccines containing HLA-A*02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics.

Dan Tan, Ning Kang, Yuanfei Zhu, Jia Hou, Hanqing Wang, Huijun Xu, Cheng Zu, Zixiang Gao, Mu Liu, Nannan Liu and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Dan TanKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Ning KangKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Yuanfei ZhuKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Jia HouKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Hanqing WangKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Huijun XuKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Cheng ZuKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Zixiang GaoKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Mu LiuKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Nannan LiuKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Qiang DengKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Hongzhou LuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Jing LiuKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Youhua XieKey Laboratory of Medical Molecular Virology (NHC & MOE & CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200031, China.
Shanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines play essential roles in the fight against the COVID-19 pandemic. The development and assessment of COVID-19 vaccines have generally focused on the induction and boosting of neutralizing antibodies targeting the SARS-CoV-2 spike (S) protein. Due to rapid and continuous variation in the S protein, such vaccines need to be regularly updated to match newly emerged dominant variants. T-cell vaccines that target MHC I- or II-restricted epitopes in both structural and non-structural viral proteins have the potential to induce broadly cross-protective and long-lasting responses. In this work, the entire proteome encoded by SARS-CoV-2 (Wuhan-hu-1) is subjected to immunoinformatics-based prediction of HLA-A*02:01-restricted epitopes. The immunogenicity of the predicted epitopes is evaluated using peripheral blood mononuclear cells from convalescent Wuhan-hu-1-infected patients. Furthermore, predicted epitopes that are conserved across major SARS-CoV-2 lineages and variants are used to construct DNA vaccines expressing multi-epitope polypeptides. Most importantly, two DNA vaccine constructs induce epitope-specific CD8

Indexed as

Computational BiologyCOVID-19COVID-19 VaccinesEpitopes, T-LymphocyteHLA-A2 AntigenSARS-CoV-2Vaccines, DNAAnimalsFemaleHumansImmunoinformaticsMiceMice, Inbred BALB CSpike Glycoprotein, CoronavirusCOVID-19 VaccinesEpitopes, T-LymphocyteHLA-A*02:01 antigenHLA-A2 AntigenSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, DNACD8 T cellcellular immune responseCOVID-19DNA vaccineSARS-CoV-2

Identifiers

PMID38655616
PMCPMC11322877
OpenAlexW4392768546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.