ArticleFrontiers in public health2024
Association of two novel systemic inflammatory biomarkers and frailty based on NHANES 2007-2018.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Interpretable machine learning framework for frailty risk prediction using NHANES 2007-2018: A cross-sectional study.Medicine · 2026Article
- Frailty index is positively associated with stroke risk in nationally representative cohorts from the united States and China.Scientific reports · 2025Article
- A prediction model for persistent postoperative frailty in older patients undergoing elective orthopedic surgery.Medicine · 2025Article
- Association between alpha-1-acid glycoprotein and frailty in US females aged 20-49 years: analysis of NHANES data (2015-2023).Scientific reports · 2025Article
- The association of body roundness index and body mass index with frailty and all-cause mortality: a study from the population aged 40 and above in the United States.Lipids in health and disease · 2025Article
- Systemic immune inflammation index and systemic inflammation response index predict frailty progression in older patients undergoing elective orthopedic surgery.Frontiers in surgery · 2025Article
- The association between a dietary index for the gut microbiota and frailty in older adults: emphasising the mediating role of inflammatory indicators.Frontiers in nutrition · 2025Article
- Cross-sectional association between hs-CRP/HDL-C ratio and physical frailty among middle-aged and older adults: findings from a population-based study.Frontiers in public health · 2025Article
- Article
- Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD.Clinical interventions in aging · 2025Article
- Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study.Frontiers in nutrition · 2025Article
- Article
- Cardiovascular Health Optimization Through Life's Essential 8 Scores Reduces Gestational Diabetes Risk: Mediation by Platelet Activity and Inflammatory Pathways in a Nationwide Cohort.International journal of women's health · 2025Article
- Association of platelet-to-HDL cholesterol ratio with frailty and all-cause mortality.Lipids in health and disease · 2024Article
- Associations of neutrophil/high-density lipoprotein cholesterol ratio with frailty and its mortality.Frontiers in endocrinology · 2024Article
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4 authors.
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Abstract
Background: Frailty is a significant concern in the field of public health. However, currently, there is a lack of widely recognized and reliable biological markers for frailty. This study aims to investigate the association between systemic inflammatory biomarkers and frailty in the older adult population in the United States. Methods: This study employed data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2018 and conducted a rigorous cross-sectional analysis. We constructed weighted logistic regression models to explore the correlation between the Systemic Immune-Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), and frailty in the population aged 40 to 80 years. Using restricted cubic spline (RCS), we successfully visualized the relationship between SII, SIRI, and frailty. Finally, we presented stratified analyses and interaction tests of covariates in a forest plot. Results: This study involved 11,234 participants, 45.95% male and 54.05% female, with an average age of 64.75 ± 0.13 years. After adjusting for relevant covariates, the weighted logistic regression model indicated an odds ratio (OR) and 95% confidence interval(CI) for the correlation between frailty and the natural logarithm (ln) transformed lnSII and lnSIRI as 1.38 (1.24-1.54) and 1.69 (1.53-1.88), respectively. Subsequently, we assessed different levels of lnSII and lnSIRI, finding consistent results. In the lnSII group model, the likelihood of frailty significantly increased in the fourth quartile (OR = 1.82, 95% CI: 1.55-2.12) compared to the second quartile. In the lnSIRI group model, the likelihood of frailty significantly increased in the third quartile (OR = 1.30, 95% CI: 1.10-1.53) and fourth quartile (OR = 2.29, 95% CI: 1.95-2.70) compared to the second quartile. The interaction results indicate that age and income-to-poverty ratio influence the association between lnSIRI and frailty. RCS demonstrated a nonlinear relationship between lnSII, lnSIRI, and frailty. Conclusion: The results of this cross-sectional study indicate a positive correlation between systemic inflammatory biomarkers (SII, SIRI) and frailty.
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