SynthesisFrontiers in public health2024
Cannabis use and mood disorders: a systematic review.
Synthesis in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 35 citations in OpenAlex.
- Randomised controlled trial of clozapine in resistant schizophrenia and schizoaffective disorder.Journal of psychopharmacology (Oxford, England) · 2025Trial
- Association between problematic internet use and depressive symptoms among individuals at high-risk of cannabis use disorder: a cross-sectional study in Quebec (Canada).Addictive behaviors reports · 2026Article
- Exploring Potential Predictors and Mediators of Marijuana Use Among US Women: A Structural Equation Modeling Approach.Preventing chronic disease · 2026Article
- Associations of Cannabis and Tobacco Use With Suicide Attempt, Suicide Death, and Overdose Death Among Veterans Prescribed Opioid Analgesics.American journal of preventive medicine · 2026Article
- Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.Molecular psychiatry · 2026Article
- Beyond cannabis use severity: associations of cannabis product type with sleep quality and mental health.Psychopharmacology · 2026Article
- Who is at risk? Core mental health symptoms and problematic cannabis use in Germany.Journal of cannabis research · 2026Article
- Article
- Influence of cannabis use on length of stay in patients admitted to the epilepsy monitoring unit.Epilepsy & behavior reports · 2026Article
- Cannabis and nicotine use are independently associated with adverse surgical, medical, and psychosocial outcomes following upper extremity fracture fixation.Journal of orthopaedic surgery and research · 2026Article
- Provider Perspectives of Conversations and Practices Surrounding Perinatal Cannabis Use.Cannabis (Albuquerque, N.M.) · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cannabis use among primary care patients with depression and anxiety disorders: cross-sectional analysis in a large health system in Los Angeles, CA.Journal of cannabis research · 2025Article
- Paradox of protection: Re-examining cannabis use disorder in sepsis outcomes among cancer patients.World journal of critical care medicine · 2025Article
- Cannabis Use and Glutamate across the Psychosis Spectrum: In Vivo Evidence from 7T Proton Magnetic Resonance Spectroscopy.Research square · 2025Article
- Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort.Journal of cannabis research · 2025Article
- Article
- Mood instability as a transdiagnostic predictor of cannabis use in attention-deficit/hyperactivity disorder and depression: A natural language processing analysis of electronic health records from 13,025 adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The NNDC Road Map for Depression Care and Focused Areas of Research.Focus (American Psychiatric Publishing) · 2025Article
- Comorbid Cannabis Use and Mood Disorders Among Adolescents.Focus (American Psychiatric Publishing) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Problematic cannabis use is highly prevalent among people with mood disorders. This underscores the need to understand the effects of cannabis and cannabinoids in this population, especially considering legalization of recreational cannabis use. Objectives: We aimed to (1) systematically evaluate cross-sectional and longitudinal studies investigating the interplay between cannabis use, cannabis use disorder (CUD), and the occurrence of mood disorders and symptoms, with a focus on major depressive disorder (MDD) and bipolar disorder (BD) and; (2) examine the effects of cannabis on the prognosis and treatment outcomes of MDD and BD. Methods: Following PRISMA guidelines, we conducted an extensive search for English-language studies investigating the potential impact of cannabis on the development and prognosis of mood disorders published from inception through November 2023, using EMBASE, PsycINFO, PubMed, and MEDLINE databases. Results: Our literature search identified 3,262 studies, with 78 meeting inclusion criteria. We found that cannabis use is associated with increased depressive and manic symptoms in the general population in addition to an elevated likelihood of developing MDD and BD. Furthermore, we observed that cannabis use is linked to an unfavorable prognosis in both MDD or BD. Discussion: Our findings suggest that cannabis use may negatively influence the development, course, and prognosis of MDD and BD. Future well-designed studies, considering type, amount, and frequency of cannabis use while addressing confounding factors, are imperative for a comprehensive understanding of this relationship. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023481634.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.