ArticleHeliyon2024
Quantitative analysis of noninvasive deep temporal interference stimulation: A simulation and experimental study.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- [Progresses on temporal interference electromagnetic stimulation for non-invasive deep brain function modulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Pooled it
- Advances in the application of temporal interference stimulation: a scoping review.Frontiers in human neuroscience · 2025Pooled it
- Temporal Interference Electrical Stimulation for Neuropsychiatric Disorders: Mechanisms, Applications, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study.Nature communications · 2025Article
- Beyond the surface: a review of transcranial temporal interference stimulation for deep brain modulation.Frontiers in neurology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Deep brain stimulation (DBS) is a method for stimulating deep regions of the brain for the treatment of various neurological and psychiatric disorders such as depression, obsessive-compulsive disorder, addiction, and Parkinson's disease. Generally, DBS can be performed using both invasive and non-invasive approaches. Invasive DBS is associated with several problems, including intracranial bleeding, infection, and changes in the position of the electrode tip. Temporal interference (TI) stimulation is a non-invasive technique used to stimulate deep regions of the brain by applying two high-frequency sinusoidal currents with slightly different frequencies. New method: This paper presents insights into the response of the spiking in the Hodgkin-Huxley (HH) neuron model of the rat somatosensory cortex by changing the parameters carrier frequency, current ratio, and difference frequency of TI stimulation. Furthermore, in order to experimentally evaluate the effect of TI stimulation on the activation of the left motor cortex, an experiment was conducted to measure the motion induced by the balanced and unbalanced TI stimulation. In the experiment, a three-axis accelerometer was attached to the right hand of the animal to determine the position of the hand. Results: Simulation results of the HH model showed that the frequency of the envelope of the TI stimulation is identical to the fundamental frequency of the neuron spikes. This result was obtained for difference frequencies of 6 Hz and 9 Hz in balanced and unbalanced TI stimulations. Moreover specifically, when the difference frequency is set to zero, the carrier frequency is within the range of 1300-1400 Hz, and the current range is between 140 and 250 μA/cm Comparison with existing method: The results of the spatial spectrum of the rat hand movement were consistent with the spectrum information of the simulation results. Additionally, steering the interfering region to the left motor cortex leads to noticeable contralateral movement of the right hand while no movement was observed in the right hand during the stimulation of the right motor cortex. Conclusion: This technique of stimulation for the deep regions of the brain is a promising tool to noninvasively treat various neurological and psychiatric disorders such as morphine dependence in addicted rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.