Evidence map›Paper›PMID 38655145›Full record

ArticleToxicology research2024

Comparative safety, pharmacokinetics, and off-target assessment of 1,1-bis(3'-indolyl)-1-(

Savannah M Rocha, Daniel L Gustafson, Stephen Safe, Ronald B Tjalkens

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Savannah M RochaDepartment of Environmental and Radiological Health Sciences, Colorado State University, 1680 Campus Delivery Fort Collins, CO 80523, USA.
Daniel L GustafsonDepartment of Clinical Sciences, Colorado State University, 1678 Campus Delivery Fort Collins, CO 80523, USA.
Stephen SafeDepartment of Veterinary Physiology and Pharmacology, Texas A&M School of Veterinary, Medicine & Biomedical Sciences, 4466 TAMU College Station, TX 77843-4466, USA.
Ronald B TjalkensDepartment of Environmental and Radiological Health Sciences, Colorado State University, 1680 Campus Delivery Fort Collins, CO 80523, USA.ORCID https://orcid.org/0000-0002-6848-4115
Colorado State University · USTexas A&M University · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Sakhila Banu · 2019 to 2026
$13.0M
Deciphering innate immune signaling mechanisms in glial cells linking lifetime environmental exposures to neuroinflammation, protein aggregation and neurodegeneration in Parkinsons diseaseR35ES035043 · NIEHS · COLORADO STATE UNIVERSITY · PI RONALD TJALKENS · 2023 to 2026
$4.4M
NCI NIH HHS P30 CA046934NIEHS NIH HHS P30 ES029067NIEHS NIH HHS R35 ES035043
6 · The paper itself

Abstract

The modified phytochemical derivative, 1,1-bis(3'-indolyl)-1-(

Indexed as

11-bis(3′-indolyl)-1-(p-chlorophenyl) methanecancerneurodegenerationoff-target bindingpharmacokineticspreclinical safety

Identifiers

PMID38655145
PMCPMC11033559
OpenAlexW4395005863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.