Evidence map›Paper›PMID 38655117›Full record

ArticleNeurotrauma reports2024

Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography.

Tracy Butler, Julia Schubert, Nikolaos A Karakatsanis, Xiuyuan Hugh Wang, Ke Xi, Yeona Kang, Kewei Chen, Liangdong Zhou, Edward K Fung, Abigail Patchell and 8 more

Open access · goldAbstract read
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Tracy ButlerDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Julia SchubertCentre for Neuroimaging Sciences, King's College London, London, United Kingdom.
Nikolaos A KarakatsanisDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Xiuyuan Hugh WangDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Ke XiDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Yeona KangDepartment of Mathematics, Howard University, Washington, DC, USA.
Kewei ChenDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Liangdong ZhouDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Edward K FungDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Abigail PatchellDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Abhishek JaywantDepartment of Psychiatry, Weill Cornell Medicine, New York, New York, USA.
Yi LiDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Gloria ChiangDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Lidia GlodzikDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Henry RusinekDepartment of Radiology, New York University School of Medicine, New York, New York, USA.
Mony de LeonDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Federico TurkheimerCentre for Neuroimaging Sciences, King's College London, London, United Kingdom.
Sudhin A ShahDepartment of Radiology, Weill Cornell Medicine, New York, New York, USA.
Cornell University · USWellcome Centre for Human Neuroimaging · GBHoward University · USNew York University · US

Funding

Brain fluid clearance and misfolded protein dynamics following traumatic brain injuryR01AG077576 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, TRACY A., LI, YI · 2023 to 2025
$4.6M
Multi-Modal Imaging of the Mechanisms Underlying Impaired Executive Attention After Traumatic Brain InjuryR01NS102646 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KUCEYESKI, AMY FRANCES, SHAH, SUDHIN · 2018 to 2022
$2.8M
CSF clearance and brain amyloid dynamics after traumatic brain injuryR56NS111052 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, TRACY A., DE LEON, MONY J. · 2019 to 2019
$593k
NIA NIH HHS R01 AG077576NINDS NIH HHS R01 NS102646NINDS NIH HHS R56 NS111052
6 · The paper itself

Abstract

Brain fluid clearance by pathways including the recently described paravascular glymphatic system is a critical homeostatic mechanism by which metabolic products, toxins, and other wastes are removed from the brain. Brain fluid clearance may be especially important after traumatic brain injury (TBI), when blood, neuronal debris, inflammatory cells, and other substances can be released and/or deposited. Using a non-invasive dynamic positron emission tomography (PET) method that models the rate at which an intravenously injected radiolabeled molecule (in this case

Indexed as

adult brain injurycerebrospinal fluidclearanceglymphatic systemPET scanning

Identifiers

PMID38655117
PMCPMC11035850
OpenAlexW4394676190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.