ArticleGreen chemistry : an international journal and green chemistry resource : GC2024
A robust heterogeneous chiral phosphoric acid enables multi decagram scale production of optically active
Article in Green chemistry : an international journal and green chemistry resource : GC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Unlocking the Phosphoric Acid Catalyzed Asymmetric Transfer Hydrogenation of 2-Alkenyl Quinolines for Efficient Flow Synthesis of Hancock Alkaloids.Organic letters · 2025Article
- General and versatile synthesis of highly recyclable chiral phosphoric acid organocatalysts.Organic chemistry frontiers : an international journal of organic chemistry · 2024Article
- De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis.Nature communications · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
Asymmetric organocatalysis has been recognized as one of the "top 10 emerging technologies" in chemistry by IUPAC in 2019. Its potential to make chemical processes more sustainable is promising, but there are still challenges that need to be addressed. Developing new and reliable enantioselective processes for reproducing batch reactions on a large scale requires a combination of chemical and technical solutions. In this manuscript, we combine a robust immobilized chiral phosphoric acid with a new packed-bed reactor design. This combination allows scaling up of the enantioselective addition of thiols to imines from a few milligrams to a multi-decagram scale in a continuous flow process without physical or chemical degradation of the catalyst.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.