Evidence map›Paper›PMID 38654970›Full record

ArticleOpen forum infectious diseases2024

Clinical and Demographic Factors Associated With Kaposi Sarcoma-Associated Herpesvirus Shedding in Saliva or Cervical Secretions in a Cohort of Tanzanian Women.

Anna M Mertelsmann, Crispin Mukerebe, Donald Miyaye, Peter Shigella, Loyce Mhango, Peter Lutonja, Paul L A M Corstjens, Claudia de Dood, Govert J van Dam, Soledad Colombe and 8 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 4 countries.

Anna M MertelsmannDivision of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0003-4448-0600
Crispin MukerebeMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Donald MiyayeMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Peter ShigellaMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Loyce MhangoMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Peter LutonjaMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Paul L A M CorstjensDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Claudia de DoodDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
Govert J van DamDepartment of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
Soledad ColombeOutbreak Research Team, Institute of Tropical Medicine, Antwerp, Belgium.
Jane K MagangaMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Christine AristideCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Samuel E KalluvyaDepartment of Medicine, Bugando Medical Centre, Mwanza, Tanzania.
Maureen M WardCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Alexandra A CordeiroCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
Myung Hee LeeCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.
John M ChangaluchaMwanza Intervention Trials Unit, National Institute for Medical Research, Mwanza, Tanzania.
Jennifer A DownsCenter for Global Health, Weill Cornell Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0001-9537-204X
Mwanza Intervention Trials Unit · TZCornell University · USLeiden University Medical Center · NLBugando Medical Centre · TZInstituut voor Tropische Geneeskunde · BE

Funding

T32: Pathogenesis of Infectious Diseases Training ProgramT32AI007613 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 1999 to 2026
$8.8M
Genital Immune, Mucosal, and Viral Effects of Female Genital Schistosomiasis in TanzaniaR01AI168306 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jennifer Alzos Downs · 2022 to 2026
$3.1M
Schistosomiasis and Women's Reproductive HealthK24AI182638 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jennifer Alzos Downs · 2024 to 2026
$611k
NIAID NIH HHS K24 AI182638NIAID NIH HHS R01 AI168306NIAID NIH HHS T32 AI007613
6 · The paper itself

Abstract

Background: Reasons for the high prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in sub-Saharan Africa, and risk factors leading to viral reactivation and shedding, remain largely undefined. Preliminary studies have suggested that schistosome infection, which has been associated with impaired viral control, is associated with KSHV. In this study we sought to determine the relationship between active Methods: We quantified KSHV DNA in saliva and cervical swabs from 2 cohorts of women living in northwestern Tanzanian communities endemic for Results: Among 139 total women, 44.6% were KSHV seropositive. Six percent of those with Conclusions: In an area with high KSHV seroprevalence and endemic schistosome infections, we provide the first report with data demonstrating no association between schistosome infection and salivary or cervical herpesvirus shedding. KSHV salivary shedding was associated with infertility, a known effect of another herpesvirus, human herpesvirus 6.

Indexed as

Kaposi sarcoma–associated herpesvirusschistosomiasisS haematobiumS mansoniviral reactivation

Identifiers

PMID38654970
PMCPMC11036159
OpenAlexW4392938168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.