ArticleFrontiers in endocrinology2024
Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 8 citations in OpenAlex.
- Speckle-tracking carotid strain ultrasonography for assessment of vascular dysfunction in metabolic syndrome: a cross-sectional study.BMC medical imaging · 2026Article
- Association of cumulative exposure and dynamic change patterns of metabolic syndrome score with cardiometabolic multimorbidity progression among middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Utility of the US Metabolic Syndrome Severity Calculator for Group-Level Comparison in Estonia.Medicina (Kaunas, Lithuania) · 2026Article
- A protocol for the impact of Tongmai Jiangtang capsules on the risk of cardiovascular and cerebrovascular events in metabolic syndrome.Frontiers in cardiovascular medicine · 2026Article
- Quantifying Metabolic Syndrome Severity: Methodological Evolution, Clinical Validation, and Translational Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Temporal relationship between inflammation and metabolic disorders and its influence on atherosclerotic cardiovascular disease.Frontiers in cardiovascular medicine · 2025Article
- Optimal Cut-off Points of the Standardized Continuous Metabolic Syndrome Severity Score (cMetS-S) for Predicting Cardiovascular Disease (CVD) and CVD Mortality in the Tehran Lipid and Glucose Study (TLGS).International journal of endocrinology and metabolism · 2024Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults. Methods: 13,500 participants from the Zhejiang Adult Chronic Disease Study were followed up between 2010 and 2021. A continuous MetS severity score derived from the five components of MetS was used to quantify MetS severity, and the association between MetS severity and the risk of incident CVD was assessed using Cox proportional hazard and restricted cubic spline regression. Results: Both the presence and severity of MetS were strongly associated with CVD risk. MetS was related to an increased risk of CVD (hazard ratio(HR):1.700, 95% confidence interval(CI): 1.380-2.094). Compared with the hazard ratio for CVD in the lowest quartile of the MetS severity score, that in the second, third, and highest quartiles were 1.812 (1.329-2.470), 1.746 (1.265-2.410), and 2.817 (2.015-3.938), respectively. A linear and positive dose-response relationship was observed between the MetS severity and CVD risk ( Conclusion: The MetS severity score was significantly associated with CVD risk. Assessing MetS severity and further ensuring intervention measures according to the different severities of MetS may be more useful in preventing CVD.
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