Evidence map›Paper›PMID 38654391›Full record

ArticleCritical care (London, England)2024

Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome.

Elias Baedorf-Kassis, Michael Murn, Amy L Dzierba, Alexis L Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M Goodspeed, Michael A Matthay and 6 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Elias Baedorf-KassisDivision of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Michael MurnColumbia Respiratory Critical Care Trials Group, Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Amy L DzierbaColumbia Respiratory Critical Care Trials Group, Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Alexis L SerraColumbia Respiratory Critical Care Trials Group, Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Ivan GarciaColumbia Respiratory Critical Care Trials Group, Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Emily MinusDepartments of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA.
Clarissa PadillaColumbia Respiratory Critical Care Trials Group, Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA.
Todd SargeDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Valerie M GoodspeedDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Michael A MatthayDepartments of Medicine and Anesthesia, University of California San Francisco, San Francisco, CA, USA.
Michelle N GongDepartment of Critical Care Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Deborah CookSt. Joseph's Hospital and McMaster University, Hamilton, ON, Canada.
Stephen H LoringDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Daniel TalmorDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Jeremy R BeitlerColumbia Respiratory Critical Care Trials Group, Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, 622 West 168th Street, New York, NY, 10032, USA. jrb2266@cumc.columbia.edu.
EPVent-2 Study Group
Beth Israel Deaconess Medical Center · USNewYork–Presbyterian Hospital · USAlbert Einstein College of Medicine · USSt. Joseph's Hospital · CAUniversity of California, San Francisco · US

Funding

Sub Project 2UM1HL108724 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LORING, STEPHEN H, TALMOR, DANIEL STUART · 2012 to 2014
$4.6M
Respiratory Drive in Acute Respiratory FailureR01HL168102 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jeremy R. Beitler · 2023 to 2026
$3.2M
Measuring lung stress to identify occult ventilation-induced lung injury in ARDSR21HL145506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BEITLER, JEREMY R. · 2019 to 2020
$243k
NHLBI NIH HHS R01 HL168102NHLBI NIH HHS R21 HL145506NHLBI NIH HHS R21-HL145506NHLBI NIH HHS UM1-HL108724
6 · The paper itself

Abstract

backgroundIn acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid-base state, oxygenation, mechanics, and sedation depth do not fully explain drive heterogeneity. This study evaluated the relationship of systemic inflammation and vascular permeability markers with respiratory drive and clinical outcomes in ARDS.

methodsARDS patients enrolled in the multicenter EPVent-2 trial with requisite data and plasma biomarkers were included. Neuromuscular blockade recipients were excluded. Respiratory drive was measured as P

results54.8% of 124 included patients had detectable respiratory drive (P

conclusionsAmong patients with ARDS, systemic inflammatory and vascular permeability markers were independently associated with higher respiratory drive. The heterogeneous response of respiratory drive to varying sedation depth may be explained in part by differences in inflammation and vascular permeability.

Indexed as

BiomarkersCapillary PermeabilityInflammationRespiratory Distress SyndromeAgedAngiopoietin-2FemaleHumansInterleukin-6Interleukin-8MaleMiddle AgedRespiratory MechanicsAngiopoietin-2BiomarkersInterleukin-6Interleukin-8Acute respiratory distress syndromeHypnotics and sedativesMechanical ventilationRespiratory mechanicsWork of breathing

Identifiers

PMID38654391
PMCPMC11036740
OpenAlexW4395039766

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.