Evidence map›Paper›PMID 38654215›Full record

ArticleBMC infectious diseases2024

A challenging case of carbapenem resistant Klebsiella pneumoniae-related pyogenic liver abscess with capsular polysaccharide hyperproduction: a case report.

Maryam Sohrabi, Neda Pirbonyeh, Mahvash Alizade Naini, Alireza Rasekhi, Abbas Ayoub, Zahra Hashemizadeh, Fereshteh Shahcheraghi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Pharmaceuticals (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maryam SohrabiDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Neda PirbonyehDepartment of Microbiology, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahvash Alizade NainiDepartment of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza RasekhiDepartment of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Abbas AyoubDepartment of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Zahra HashemizadehDepartment of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Fereshteh ShahcheraghiDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, Iran. Shahcheraghifereshteh@yahoo.com.
Shiraz University of Medical Sciences · IRPasteur Institute of Iran · IR

Funding

Funding was granted to Maryam Sohrabi as a Ph.D. student of the Pasteur Institute of Iran (Project No.: B-9636). Project No.: B-9636
6 · The paper itself

Abstract

backgroundCarbapenem-resistant Klebsiella pneumoniae (CRKP) infections are a major public health problem, necessitating the administration of polymyxin E (colistin) as a last-line antibiotic. Meanwhile, the mortality rate associated with colistin-resistant K. pneumoniae infections is seriously increasing. On the other hand, importance of administration of carbapenems in promoting colistin resistance in K. pneumoniae is unknown. CASE PRESENTATION: We report a case of K. pneumoniae-related pyogenic liver abscess in which susceptible K. pneumoniae transformed into carbapenem- and colistin-resistant K. pneumoniae during treatment with imipenem. The case of pyogenic liver abscess was a 50-year-old man with diabetes and liver transplant who was admitted to Abu Ali Sina Hospital in Shiraz. The K. pneumoniae isolate responsible for community-acquired pyogenic liver abscess was isolated and identified. The K. pneumoniae isolate was sensitive to all tested antibiotics except ampicillin in the antimicrobial susceptibility test and was identified as a non-K1/K2 classical K. pneumoniae (cKp) strain. Multilocus sequence typing (MLST) identified the isolate as sequence type 54 (ST54). Based on the patient's request, he was discharged to continue treatment at another center. After two months, he was readmitted due to fever and progressive constitutional symptoms. During treatment with imipenem, the strain acquired bla

conclusionsBased on this information, can we have a theoretical hypothesis that imipenem is a promoter of resistance to carbapenems and colistin in K. pneumoniae? This needs more attention.

Indexed as

Anti-Bacterial AgentsCarbapenemsColistinKlebsiella InfectionsKlebsiella pneumoniaeLiver Abscess, PyogenicMicrobial Sensitivity TestsCarbapenem-Resistant EnterobacteriaceaeDrug Resistance, Multiple, BacterialHumansImipenemMaleMiddle AgedMultilocus Sequence TypingAnti-Bacterial AgentsCarbapenemsColistinImipenemCapsular polysaccharideCarbapenem-resistantColistinKlebsiella pneumoniaePathogenesis

Identifiers

PMID38654215
PMCPMC11040961
OpenAlexW4395037783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.