Evidence map›Paper›PMID 38654183›Full record

ArticleBMC nephrology2024

The clinical utility of cystatin C based eGFR in assessing renal function among HIV/AIDs patients on ART at Mildmay Uganda.

Enock Wekiya, Godfrey P Mujuzi, Jane Nakiyingi, Juliet Sanya, Moses Matovu, Ocung Guido, Jane Nakaweesi, Charles Karamagi, Joan K Nakayaga, Edrisa I Mutebi and 1 more

Open access · goldAbstract read
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Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Enock WekiyaMildmay Uganda, P.O Box 24985, Kampala, Uganda. wekiaeric@gmail.com.
Godfrey P MujuziCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Jane NakiyingiMildmay Uganda, P.O Box 24985, Kampala, Uganda.
Juliet SanyaMildmay Uganda, P.O Box 24985, Kampala, Uganda.
Moses MatovuCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Ocung GuidoCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Jane NakaweesiMildmay Uganda, P.O Box 24985, Kampala, Uganda.
Charles KaramagiCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Joan K NakayagaCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Edrisa I MutebiCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Damalie NakanjakoCollege of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Makerere University · UGMildmay Uganda · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn clinical practice, Measurement of estimated glomerular filtration rates (eGFR) is the gold standard assessing renal function the glomerular filtration rate often estimated from plasma creatinine. Several studies have shown Cystatin C based eGFR (Cys C) to be a better parameter for the diagnosis of impaired renal function. Cystatin C based eGFR has been proposed as a potential renal function marker but its use in HIV&AIDS patients has not been well evaluated.

methodsA cross sectional study was carried out on 914 HIV&AIDS patients on antiretroviral therapy (ART) attending Mildmay Uganda for care and treatment between January to March 2015. Serum Cystatin C based eGFR was measured using the particle enhanced immunoturbidimetric assay. Creatinine was analyzed using enzymatic Creatinine PAP method and creatinine clearance was calculated according to C&G.

resultsThe sensitivity of Cystatin C based eGFR was 15.1% (95% CI = 8.4, 24) with specificity 99.3% (95% CI = 98- 99.7). The positive and negative predictive values were 70.0% (95% CI 45.7-88.1) and 91.2% (95% CI 98.11-92.94) respectively. The positive likelihood ratio was 18.81 and negative likelihood ratio was 0.85. Cystatin C based eGFR had diagnostic accuracy of 90.7 and area under curve was 0.768.

conclusionCystatin C based eGFR exhibited a high specificity and a high positive likelihood ratio in diagnosis of kidney disease among HIV&AIDS patients. Cystatin C based eGFR can be used as a confirmatory test.

Indexed as

Cystatin CGlomerular Filtration RateHIV InfectionsAcquired Immunodeficiency SyndromeAdultBiomarkersCreatinineCross-Sectional StudiesFemaleHumansMaleMiddle AgedSensitivity and SpecificityUgandaBiomarkersCreatinineCystatin CCockcroft and GaultCreatinineCystatin C based eGFRGlomerular filtration rateLikelihood ratioROC analysisSensitivitySpecificity

Identifiers

PMID38654183
PMCPMC11036554
OpenAlexW4395043863

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.