Evidence map›Paper›PMID 38654064›Full record

ArticleScientific reports2024

Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis.

Mark B Wiley, Jessica Bauer, Valentina Alvarez, Kunaal Mehrotra, Wenxuan Cheng, Zoe Kolics, Michael Giarrizzo, Komala Ingle, Agnieszka B Bialkowska, Barbara Jung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mark B WileyDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Jessica BauerDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.ORCID 0000-0001-9022-9877
Valentina AlvarezDepartment of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Kunaal MehrotraDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Wenxuan ChengDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Zoe KolicsDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Michael GiarrizzoDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, 11794, USA.
Komala IngleDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, 11794, USA.
Agnieszka B BialkowskaDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, 11794, USA.
Barbara JungDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. bhjung@uw.edu.
University of Washington · USStony Brook School · USSeattle Pacific University · US

Funding

Mechanisms of injury-induced pancreatic neoplasiaR01DK124342 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI BIALKOWSKA, AGNIESZKA BEATA · 2020 to 2023
$1.4M
NIDDK NIH HHS R01 DK124342
6 · The paper itself

Abstract

Acute Pancreatitis (AP) is associated with high mortality and current treatment options are limited to supportive care. We found that blockade of activin A (activin) in mice improves outcomes in two murine models of AP. To test the hypothesis that activin is produced early in response to pancreatitis and is maintained throughout disease progression to stimulate immune cells, we first performed digital spatial profiling (DSP) of human chronic pancreatitis (CP) patient tissue. Then, transwell migration assays using RAW264.7 mouse macrophages and qPCR analysis of "neutrophil-like" HL-60 cells were used for functional correlation. Immunofluorescence and western blots on cerulein-induced pancreatitis samples from pancreatic acinar cell-specific Kras knock-in (Ptf1aCre

Indexed as

ActivinsCell MovementMacrophagesNeutrophil ActivationPancreatitisSignal TransductionAnimalsDisease Models, AnimalHL-60 CellsHumansMacrophage ActivationMaleMiceNeutrophilsPancreatitis, ChronicRAW 264.7 Cellsactivin AActivinsActivin AAcute pancreatitisCeruleinChronic pancreatitisDigital spatial profiling

Identifiers

PMID38654064
PMCPMC11039671
OpenAlexW4395051303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.