ReviewPaediatric drugs2024
Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship.
Review in Paediatric drugs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Piperacillin/tazobactam versus ceftriaxone/metronidazole for children with perforated appendicitis: a systematic review and meta-analysis.Pediatric surgery international · 2025Pooled it
- A systematic review of risk stratification for pediatric appendicitis.Pediatric surgery international · 2025Pooled it
- Bacterial Etiology and Antimicrobial Susceptibility Patterns in Pediatric Intra-Abdominal Infections-Implications for Empirical Treatment and Antimicrobial Stewardship.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Diagnostic value of pediatric appendicitis score for complicated appendicitis in preschool children.BMC pediatrics · 2026Article
- Postoperative outcomes following institutional antibiotic protocol changes in complicated pediatric appendicitis.World journal of pediatric surgery · 2026Article
- Jujube pit ingestion leading to ileal perforation and secondary acute appendicitis in a child: a case report.AME case reports · 2026Article
- Differences in microbiota profiles of simple and complicated pediatric appendicitis cases.Frontiers in cellular and infection microbiology · 2026Article
- Transrectal Endoscopic Ultrasound-Guided Drainage of a Deep Pelvic Abscess in a Postoperative Pediatric Patient: A Case Report.Clinical case reports · 2025Article
- Comparison of the efficacy of carbapenems and cephalosporins for postoperative treatment of perforated appendicitis in children.World journal of gastrointestinal surgery · 2025Article
- Surgical delay in appendicitis among children: the role of social vulnerability.Frontiers in pediatrics · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although appendicitis has been described for more than 300 years, its optimal management remains a topic of active investigation. Acute appendicitis is the most common cause of peritonitis in children, and rates of perforated appendicitis are much higher in children than in adults. Increased risk for perforated appendicitis in children is related to a delay in diagnosis due to age, size, access to care, and more. Surgical options include immediate appendectomy versus nonoperative management with intravenous antibiotics ± a drainage procedure, with a subsequent interval appendectomy. Microbiota of perforated appendicitis in children most often includes Escherichia coli, Bacteroides fragilis, Streptococcus, and more. Even though the most common organisms are known, there is a large variety of practice when it comes to postoperative antibiotic management in these patients. Studies discuss the benefits of mono- versus dual or triple therapy without a particular consensus regarding what to use. This is reflected across differing practices at various institutions. In this review, we aim to explore the implications of perforated appendicitis in pediatrics, common organisms seen, antibiotic regimen coverage, and the implications of variations of practice. Resistance to commonly used broad-spectrum antibiotics is evolving, therefore minimization of care variability is needed for improved patient outcomes and proper antibiotic stewardship.
Indexed as
Identifiers
38653916What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.