Evidence map›Paper›PMID 38653877›Full record

ArticleCellular and molecular life sciences : CMLS2024

Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.

Dipti Verma, Ankita Singh, Jyoti Singh, Mousumi Mutsuddi, Ashim Mukherjee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dipti VermaDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Ankita SinghDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Jyoti SinghDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Mousumi MutsuddiDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
Ashim MukherjeeDepartment of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India. amukherjee@bhu.ac.in.ORCID http://orcid.org/0000-0002-3523-7089
Banaras Hindu University · IN

Funding

DST, GoI CRG/2021/006975IoE, BHU R/Dev/D/IoE/Incentive/2021-2022
6 · The paper itself

Abstract

The Notch pathway is an evolutionarily conserved signaling system that is intricately regulated at multiple levels and it influences different aspects of development. In an effort to identify novel components involved in Notch signaling and its regulation, we carried out protein interaction screens which identified non-muscle myosin II Zipper (Zip) as an interacting partner of Notch. Physical interaction between Notch and Zip was further validated by co-immunoprecipitation studies. Immunocytochemical analyses revealed that Notch and Zip co-localize within same cytoplasmic compartment. Different alleles of zip also showed strong genetic interactions with Notch pathway components. Downregulation of Zip resulted in wing phenotypes that were reminiscent of Notch loss-of-function phenotypes and a perturbed expression of Notch downstream targets, Cut and Deadpan. Further, synergistic interaction between Notch and Zip resulted in highly ectopic expression of these Notch targets. Activated Notch-induced tumorous phenotype of larval tissues was enhanced by over-expression of Zip. Notch-Zip synergy resulted in the activation of JNK pathway that consequently lead to MMP activation and proliferation. Taken together, our results suggest that Zip may play an important role in regulation of Notch signaling.

Indexed as

Drosophila ProteinsMembrane ProteinsMyosin Heavy ChainsReceptors, NotchSignal TransductionAnimalsCell ProliferationDrosophilaDrosophila melanogasterMatrix MetalloproteinasesMyosin Type IIPhenotypeWings, AnimalDrosophila ProteinsMatrix MetalloproteinasesMembrane ProteinsMyosin Heavy ChainsMyosin Type IIN protein, DrosophilaReceptors, NotchZip protein, DrosophilaEndocytosisJNK pathwayNotch signalingRab5Zipper

Identifiers

PMID38653877
PMCPMC11039529
OpenAlexW4395081048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.