Evidence map›Paper›PMID 38653856›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

Determinants of Conception and Adverse Pregnancy Outcomes in Women with Endometriosis: A Longitudinal Study.

Hrishikesh Munshi, Tabassum Khan, Shagufta Khan, Pramathes DasMahapatra, Sheila Balakrishnan, Chelana Nirmala, Vinita Das, Ketki Kulkarni, Bimal M John, Amiya Majumdar and 4 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Hrishikesh MunshiClinical Research Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.ORCID 0000-0002-6808-5368
Tabassum KhanClinical Research Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.ORCID 0009-0009-5308-4969
Shagufta KhanClinical Research Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.
Pramathes DasMahapatraSpectrum Clinic and Endoscopy Research Institute, Kolkata, India.
Sheila BalakrishnanDepartment of Reproductive Medicine, Sree Avittam Thirunal (SAT) Hospital, Thiruvananthapuram, India.
Chelana NirmalaDepartment of Obstetrics and Gynecology, Sree Avittam Thirunal (SAT) Hospital, Thiruvananthapuram, India.
Vinita DasDepartment of Obstetrics and Gynecology, King George's Medical University (KGMU), Lucknow, India.
Ketki KulkarniNowrosjee Wadia Maternity Hospital, Mumbai, India.
Bimal M JohnMinimally Invasive Surgery Unit, Credence Hospital - Multispecialty Women's Hospital and IVF Center, Thiruvananthapuram, India.
Amiya MajumdarSpectrum Clinic and Endoscopy Research Institute, Kolkata, India.
C V SowminiDepartment of Obstetrics and Gynecology, Sree Avittam Thirunal (SAT) Hospital, Thiruvananthapuram, India.
Aarti SrivastavaDepartment of Obstetrics and Gynecology, King George's Medical University (KGMU), Lucknow, India.
Komal KhadeMolecular Endocrinology Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.
Rahul K GajbhiyeClinical Research Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India. gajbhiyer@nirrch.res.in.ORCID 0000-0003-3864-1818
National Institute for Research in Reproductive Health · INKing George's Medical University · INSpectrum Clinical Research (India) · INBai Jerbai Wadia Hospital for Children · IN

Funding

Indian Council of Medical Research ICMR-NIRRCH/MS/RA/1613/09-2023).
6 · The paper itself

Abstract

Endometriosis, affecting approximately 10% of reproductive-aged women globally, poses significant challenges, including chronic pelvic pain, dysmenorrhea, and infertility. In low- and middle-income countries like India, accessibility to affordable infertility care remains a concern. This multicenter prospective cohort study, conducted across six tertiary care hospitals in India from 2017 to 2022, aims to explore the natural progression of conception and pregnancy outcomes in women with endometriosis. Of the 257 participants, 19.1% conceived during the study, revealing significant geographic and income-based variations (p < 0.001, p = 0.01). Dysmenorrhea (p < 0.001) and dyspareunia (p=0.027) were correlated with conception, while no such associations were found with chronic pelvic pain or menstrual factors. Lesion type, number, and severity showed no conclusive link with conception. Natural conception occurred in 70% of cases, with an average post-surgery conception time of 282.1 days. Live birth rate was 85.7%, while complications included placenta previa (16.4%), preeclampsia (4.1%), and preterm births (4.1%). This study, one of the first in India on endometriosis-related fertility progression, emphasizes the need for comprehensive understanding and management of conception and pregnancy outcomes. Considering India's substantial endometriosis burden, the study recommends prioritizing larger multicenter investigations for a better understanding and effective strategies for infertility management.

Indexed as

EndometriosisFertilizationPregnancy OutcomeAdultFemaleHumansIndiaInfertility, FemaleLongitudinal StudiesPregnancyPregnancy ComplicationsProspective StudiesConceptionEndometriosisInfertilityMulticenter studyPregnancy outcomes

Identifiers

PMID38653856
OpenAlexW4395050826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.