Evidence map›Paper›PMID 38653851›Full record

ArticleJournal of autism and developmental disorders2025

Analyzing the Quality of Life in Individuals with Fragile X Syndrome in Relation to Sleep and Mental Health.

Amrita Minhas, Kerri Whitlock, Cory Rosenfelt, Julie Shatto, Brittany Finlay, Jennifer Zwicker, Sarah Lippe, Sebastien Jacquemont, Randi Hagerman, Kara Murias and 1 more

Abstract read
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In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Amrita MinhasDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0009-0008-9331-7790
Kerri WhitlockDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-8032-4587
Cory RosenfeltDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-1422-4411
Julie ShattoDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Brittany FinlaySchool of Public Policy, University of Calgary, Calgary, AB, Canada.
Jennifer ZwickerSchool of Public Policy, University of Calgary, Calgary, AB, Canada.
Sarah LippeHopital Sainte-Justine, Universite de Montreal, Montreal, QC, Canada.
Sebastien JacquemontHopital Sainte-Justine, Universite de Montreal, Montreal, QC, Canada.
Randi HagermanMIND Institute, University of California, Sacramento, CA, USA.
Kara MuriasDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Francois V BolducDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada. fbolduc@ualberta.ca.ORCID http://orcid.org/0000-0002-6109-5467
University of Alberta · CAUniversity of Calgary · CACentre Hospitalier Universitaire Sainte-Justine · CA

Funding

Azrieli Foundation RES0041289
6 · The paper itself

Abstract

The purpose of this paper was to examine the physical, emotional, social and school functioning domains of quality of life of individuals with Fragile X Syndrome, in relation to mental health and sleep patterns to gain a better understanding of how these aspects are affected by the disorder. This study included 119 individuals with Fragile X Syndrome who were given different cognitive examinations by a neuropsychologist or by parent-proxy questionnaires. This study focused on the Pediatric Quality of Life Inventory (PedsQoL), the Anxiety, Depression and Mood Scale (ADAMS), the Children's Sleep Habits Questionnaire (CSHQ), but did include other cognitive tests (Vineland Adaptive Behaviour Scales, Nonverbal IQ, Autism Diagnostic Observation Schedule). We identified significant associations between decreases in emotional, social and school domains of PedsQoL and the ADAMS subtests of Generalized Anxiety, Manic/Hyperactivity and Obsessive/Compulsivity, with the subtest of Depressed Mood having associations with lower physical and emotional domains. We also identified a significant impact between CSHQ subtests of Sleep Anxiety, Night Wakings, Daytime Sleepiness, and Parasomnia with the emotional and school domains of PedsQoL. There were associations connecting school functioning with Bedtime Resistance, and additional associations connecting emotional functioning with Sleep Duration and Sleep Onset Delay. Physical functioning was also associated with Sleep Anxiety. Our study shows how mental health and sleep defects impact improper sleep patterns and mental health which leads to decreases in the quality of life for individuals with FXS, and how it is important to screen for these symptoms in order to alleviate issues.

Indexed as

Fragile X SyndromeMental HealthQuality of LifeSleepSleep Wake DisordersAdolescentAdultAnxietyChildDepressionFemaleHumansMaleSurveys and QuestionnairesFragile X SyndromeMental healthNeurodevelopmental disordersQuality of lifeSleep

Identifiers

PMID38653851
OpenAlexW4395029766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.