Evidence map›Paper›PMID 38653850›Full record

ArticleEcoHealth2024

Prevalence and Molecular Analysis of Encephalomyocarditis Virus-2 in the Hazel Dormouse.

Louise Gibson, Tammy Shadbolt, Pranab Paul, Georgina Gerard, Ethan Wrigglesworth, Anthony W Sainsbury, Helen Donald, Jenny E Jaffe, Inez Januszczak, Liam D Fitzpatrick and 4 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in EcoHealth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Louise Gibson *Institute of Zoology, Zoological Society of London, London, NW1 4RY, UK. Louise.gibson@ioz.ac.uk.ORCID 0000-0002-7293-1475
Tammy Shadbolt *Institute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0002-8538-2161
Pranab PaulRoyal Veterinary College, London, UK.ORCID 0000-0002-2118-6831
Georgina GerardInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0001-7725-0006
Ethan WrigglesworthInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0002-8865-5161
Anthony W SainsburyInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0002-5397-287X
Helen DonaldInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.
Jenny E JaffeInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0001-6157-337X
Inez JanuszczakInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0003-3857-9989
Liam D FitzpatrickInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.
Caela BurrellRoyal Veterinary College, London, UK.
Hannah DaviesAnimal and Plant Health Agency-Weybridge, Surrey, UK.ORCID 0000-0002-9503-4427
Akbar DastjerdiAnimal and Plant Health Agency-Weybridge, Surrey, UK.ORCID 0000-0001-6251-6588
Simon SpiroInstitute of Zoology, Zoological Society of London, London, NW1 4RY, UK.ORCID 0000-0002-9621-2192
Zoological Society of London · GBAnimal and Plant Health Agency · GBRoyal Veterinary College · GB

Funding

Natural England Ecm 65292
6 · The paper itself

Abstract

The hazel dormouse (Muscardinus avellanarius) population in the UK continues to decline due to habitat loss, despite reintroductions of captive-bred individuals being conducted nationally for over 30 years. Disease surveillance of captive-bred and wild dormice is performed to identify novel and existing disease threats which could impact populations. In this study, we firstly investigated cause of death in seven hazel dormice found dead in England, through next-generation sequencing identifying a virus closely related to a wood mouse encephalomyocarditis virus-2 (EMCV-2). Subsequently, lung tissue samples from 35 out of 44 hazel dormice tested positive for EMCV-2 RNA using a reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and Sanger sequencing methods developed in this study. Formalin-fixed tissues available for nine hazel dormice which tested positive for EMCV-2 RNA were examined microscopically. Three cases showed moderate interstitial pneumonia with minimal to mild lymphoplasmacytic myocarditis, but no evidence of encephalitis. However, the presence of possible alternative causes of death in these cases means that the lesions cannot be definitively attributed to EMCV-2. Here, we report the first detection of EMCV-2 in hazel dormice and conclude that EMCV-2 is likely to be endemic in the hazel dormouse population in England and may be associated with clinical disease.

Indexed as

Cardiovirus InfectionsEncephalomyocarditis virusAnimalsEnglandFemaleMalePrevalenceRNA, ViralRNA, ViralCardiovirusEMCV-2Encephalomyocarditis virusHazel dormouseMuscardinus avellanarius

Identifiers

PMID38653850
PMCPMC11897066
OpenAlexW4395028956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.