Evidence map›Paper›PMID 38653028›Full record

ArticleCarbohydrate research2024

Photosensitizer-thioglycosides enhance photodynamic therapy by augmenting cellular uptake.

Shuen-Shiuan Wang, Shuai Shao, Arun Singh, Ryoma Hombu, Jonathan F Lovell, Khushi L Matta, Sriram Neelamegham

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shuen-Shiuan WangDepartment of Chemical and Biological Engineering, State University of New York, Buffalo, NY, 14260, USA.
Shuai ShaoDepartment of Biomedical Engineering, State University of New York, Buffalo, NY, 14260, USA.
Arun SinghDepartment of Chemical and Biological Engineering, State University of New York, Buffalo, NY, 14260, USA.
Ryoma HombuDepartment of Chemical and Biological Engineering, State University of New York, Buffalo, NY, 14260, USA.
Jonathan F LovellDepartment of Biomedical Engineering, State University of New York, Buffalo, NY, 14260, USA.
Khushi L MattaDepartment of Chemical and Biological Engineering, State University of New York, Buffalo, NY, 14260, USA.
Sriram NeelameghamDepartment of Chemical and Biological Engineering, State University of New York, Buffalo, NY, 14260, USA; Department of Biomedical Engineering, State University of New York, Buffalo, NY, 14260, USA; Clinical and Translational Research Center, State University of New York, Buffalo, NY, 14260, USA. Electronic address: neel@buffalo.edu.
University at Buffalo, State University of New York · USBuffalo State University · US

Funding

Systems Biology of GlycosylationR01HL103411 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI NEELAMEGHAM, SRIRAM · 2011 to 2025
$7.1M
Truncated O-glycan-dependent mechanisms inducing metastatic dissemination in pancreatic cancerR01CA273349 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., PONNUSAMY, MOORTHY P. · 2022 to 2025
$2.7M
NCI NIH HHS R01 CA273349NHLBI NIH HHS R01 HL103411
6 · The paper itself

Abstract

Photodynamic therapy (PDT) uses photosensitizing agents along with light to ablate tissue, including cancers. Such light-driven localized delivery of free-radical oxygen to kill target tissue depends on photosensitizer cell penetration efficacy. While the attachment of monosaccharides and disaccharides to photosensitizers has been shown to potentially provide improved photosensitizer delivery, the range of glycan entities tested thus far is limited. We sought to expand such knowledge by coupling N-acetylglucosamine (GlcNAc) to pyropheophorbides as thioglycosides, and then testing photosensitizer efficacy. To this end, GlcNAc was conjugated to both pyropheophorbide-a and methyl pyropheophorbide-a. Among the entities tested, the conjugation of N-acetylglucosamine to methyl pyropheophorbide-a ('PSe') as thioglycoside enhanced cell uptake both in the presence and absence of human serum proteins, relative to other compounds tested. The enhanced PSe penetrance into cells resulted in higher cell death upon illumination with 665 nm light. While acting as a potent photosensitizer, PSe did not affect cellular carbohydrate profiles. Overall, the study presents a new pyropheophorbide glycoconjugate with strong in vitro PDT efficacy.

Indexed as

PhotochemotherapyPhotosensitizing AgentsThioglycosidesCell SurvivalChlorophyllHumansLightChlorophyllPhotosensitizing Agentspyropheophorbide aThioglycosidesCarbohydrateGlycoconjugatePhotodynamic therapyThioglycoside

Identifiers

PMID38653028
PMCPMC11760509
OpenAlexW4394935732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.