Evidence map›Paper›PMID 38652746›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Identification of the potassium-binding site in serotonin transporter.

Eva Hellsberg, Danila Boytsov, Qingyang Chen, Marco Niello, Michael Freissmuth, Gary Rudnick, Yuan-Wei Zhang, Walter Sandtner, Lucy R Forrest

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cytosolic KJournal of chemical theory and computation · 2026
    Article
  2. Article
  3. Control of Conformational Transitions by the Conserved GXInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Identification of the potassium-binding site in serotonin transporter.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Eva Hellsberg *Computational Structural Biology Section, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0001-9913-978X
Danila Boytsov *Center of Physiology and Pharmacology, Department of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-6200-7158
Qingyang Chen *School of Life Sciences, Higher Education Mega Center, Guangzhou University, Guangzhou 510006, China.ORCID 0009-0004-2016-1618
Marco NielloCenter of Physiology and Pharmacology, Department of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.
Michael FreissmuthCenter of Physiology and Pharmacology, Department of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0001-9398-1765
Gary RudnickDepartment of Pharmacology, Yale University, New Haven, CT 06510.ORCID 0000-0002-7622-4110
Yuan-Wei ZhangSchool of Life Sciences, Higher Education Mega Center, Guangzhou University, Guangzhou 510006, China.ORCID 0000-0002-4276-9251
Walter SandtnerCenter of Physiology and Pharmacology, Department of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0003-3637-260X
Lucy R ForrestComputational Structural Biology Section, National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0003-1855-7985
Medical University of Vienna · ATGuangzhou University · CNNational Institute of Neurological Disorders and Stroke · USYale University · US

Funding

Computational Studies of Membrane Transport ProteinsZIANS003139 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI FORREST, LUCY · 2014 to 2025
$13.7M
Conformational change in NSS transportersR01NS102277 · NINDS · YALE UNIVERSITY · PI RUDNICK, GARY W · 2017 to 2020
$2.1M
NINDS NIH HHS R01 NS102277
6 · The paper itself

Abstract

Clearance of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (SERT), which couples this process to the movement of a Na

Indexed as

Molecular Dynamics SimulationPotassiumSerotonin Plasma Membrane Transport ProteinsSodiumAnimalsBinding SitesHumansProtein BindingSerotoninPotassiumSerotoninSerotonin Plasma Membrane Transport ProteinsSodiumantiportmolecular dynamics simulationspatch clamp electrophysiologyproteoliposomestransporter

Identifiers

PMID38652746
PMCPMC11067047
OpenAlexW4395050850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.