Evidence map›Paper›PMID 38652696›Full record

ArticleChemical research in toxicology2024

Quantification of Intracellular DNA-Protein Cross-Links with N7-Methyl-2'-Deoxyguanosine and Their Contribution to Cytotoxicity.

Tingyu Wen, Shubo Zhao, Julian Stingele, Jean-Luc Ravanat, Marc M Greenberg

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Tingyu WenDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.
Shubo ZhaoGene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
Julian StingeleGene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.ORCID 0000-0001-6020-2075
Jean-Luc RavanatUniv. Grenoble Alpes, CEA, CNRS, Grenoble INP, IRIG, SyMMES, 38000 Grenoble, France.ORCID 0000-0002-7123-6358
Marc M GreenbergDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.ORCID 0000-0002-5786-6118
Johns Hopkins University · USLudwig-Maximilians-Universität München · DEInstitut polytechnique de Grenoble · FR

Funding

How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and ApplicationsR35GM131736 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MARC M GREENBERG · 2019 to 2026
$4.3M
NIGMS NIH HHS R35 GM131736
6 · The paper itself

Abstract

The major product of DNA-methylating agents, N7-methyl-2'-deoxyguanosine (MdG), is a persistent lesion

Indexed as

DeoxyguanosineDNAMethyl MethanesulfonateCell SurvivalCross-Linking ReagentsDNA-Binding ProteinsDNA DamageHeLa CellsHumansTandem Mass SpectrometryCross-Linking ReagentsDeoxyguanosineDNADNA-Binding ProteinsMethyl MethanesulfonateSPRTN protein, human

Identifiers

PMID38652696
PMCPMC11105979
OpenAlexW4395030458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.