Trial reportPain medicine (Malden, Mass.)2024
Brain compensatory mechanisms in depression and memory complaints in fibromyalgia: the role of theta oscillatory activity.
Trial report in Pain medicine (Malden, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03371225 (Optimized tDCS for Fibromyalgia), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimized tDCS for Fibromyalgia: Targeting the Endogenous Pain Control System
Who cites it
10 citing papers in PubMed, 7 citations in OpenAlex.
- Motor cortex pain compensation is modifiable: allostatic load degrades its analgesic efficiency and rehabilitation restores it.medRxiv : the preprint server for health sciences · 2026Article
- Dimethyl Fumarate and Cobalt Protoporphyrin IX Inhibit Fibromyalgia-like Pain by Modulating Region-Specific Redox Pathways.Antioxidants (Basel, Switzerland) · 2026Article
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- Neuromodulation in Parkinson's disease with transcranial pulse stimulation: evidence of clinical efficacy and cortical oscillatory changes.Journal of neurology · 2025Article
- Multimodal neuroimaging unveils basal forebrain-limbic system circuit dysregulation in cognitive impairment with depression: a pathway to early diagnosis and intervention.The journal of prevention of Alzheimer's disease · 2025Article
- Personality Assessment Inventory in Fibromyalgia: Links to Functional, Physical-Somatic, and Emotional Impact.European journal of investigation in health, psychology and education · 2025Article
- Defective Intracortical Inhibition as a Marker of Impaired Neural Compensation in Amputees Undergoing Rehabilitation.Biomedicines · 2025Article
- Neurophysiological Markers of Adaptation and Compensation Following Lower Limb Amputation: An Analysis of EEG Oscillations and Clinical Predictors from the DEFINE Cohort Study.Neurology international · 2025Article
- EEG Oscillations as Neuroplastic Markers of Neural Compensation in Spinal Cord Injury Rehabilitation: The Role of Slow-Frequency Bands.Brain sciences · 2024Article
- The Link between Endogenous Pain Modulation Changes and Clinical Improvement in Fibromyalgia Syndrome: A Meta-Regression Analysis.Biomedicines · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe different clinical presentations of fibromyalgia syndrome (FMS) might play independent roles in the unclear etiology of cognitive impairments and depressive symptoms seen in patients with FMS. Understanding how these clinical presentations are associated with the clinical and neurophysiological aspects of FMS is important for the development of effective treatments.
aimTo explore the relationship of memory complaints and depressive symptoms with the different clinical and neurophysiological characteristics of FMS.
methodsCross-sectional data analysis from a randomized clinical trial. Baseline demographics and data on physical fitness, sleep, anxiety, depression, cortical excitability, and pain (clinical and mechanistic) from 63 subjects with FMS were used. Multiple linear and logistic association models were constructed.
resultsFinal regression models including different sets of predictions were statistically significant (P < .001), explaining approximately 50% of the variability in cognitive complaints and depression status. Older subjects had higher levels of anxiety, poorer sleep quality, lower motor threshold, and higher relative theta power in the central area and were more likely to have clinical depression. Higher anxiety, pain, and theta power were associated with a higher likelihood of memory complaints.
conclusionDepression symptoms seem to be associated with transcranial magnetic stimulation-indexed motor threshold and psychosocial variables, whereas memory complaints are associated with pain intensity and higher theta oscillations. These mechanisms might be catalyzed or triggered by some behavioral and clinical features, such as older age, sleep disruption, and anxiety. The correlation with clinical variables suggests that the increasing of theta oscillations is a compensatory response in patients with FMS, which can be explored in future studies to improve the treatment of FMS.
trial registrationClinicalTrials.gov ID NCT03371225.
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