Evidence map›Paper›PMID 38652493›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2024

Sleep macro-architecture in patients with Parkinson's disease does not change during the first night of neurostimulation in a pilot study.

Rig Das, Stephen V Gliske, Leslie C West, Michael O Summers, Siqun Tang, Lisa Hirt, Dulce Maroni, Casey H Halpern, John A Thompson, Clete A Kushida and 1 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04620551 (Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04620551 nacompletednot on this map

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers in Sleep Dysregulation and Repair

TypeinterventionalSponsorUniversity of NebraskaRan2020 to 2026Enrolled20ConditionsParkinson Disease, Sleep FragmentationArmsSub-clinical stimulation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Sleep spindle variation in patients with Parkinson's disease on first nights of sub-optimal deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Rig DasDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska.
Stephen V GliskeDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska.
Leslie C WestDepartment of Neurology, University of California San Francisco, San Francisco, California.
Michael O SummersDivision of Pulmonary, Critical Care and Sleep Medicine, Nebraska Medicine Sleep Center, Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Siqun TangSleep Medicine Division, Department of Psychiatry and Behavioral Science, Stanford University, Stanford, California.
Lisa HirtDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Dulce MaroniDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska.
Casey H HalpernDepartment of Neurosurgery, University of Pennsylvania School of Medicine, Richards Medical Research Laboratories, Pennsylvania Hospital, Philadelphia, Pennsylvania.
John A ThompsonDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Clete A KushidaSleep Medicine Division, Department of Psychiatry and Behavioral Science, Stanford University, Stanford, California.
Aviva AboschDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska.
University of Nebraska Medical Center · USStanford University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US

Funding

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and RepairUH3NS113769 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ABOSCH, AVIVA, HALPERN, CASEY HARRISON · 2020 to 2025
$5.2M
NINDS NIH HHS UH3 NS113769
6 · The paper itself

Abstract

STUDY

objectivesA growing body of literature suggests that deep brain stimulation to treat motor symptoms of Parkinson's disease may also ameliorate certain sleep deficits. Many foundational studies have examined the impact of stimulation on sleep following several months of therapy, leaving an open question regarding the time course for improvement. It is unknown whether sleep improvement will immediately follow onset of therapy or accrete over a prolonged period of stimulation. The objective of our study was to address this knowledge gap by assessing the impact of deep brain stimulation on sleep macro-architecture during the first nights of stimulation.

methodsPolysomnograms were recorded for 3 consecutive nights in 14 patients with advanced Parkinson's disease (10 male, 4 female; age: 53-74 years), with intermittent, unilateral subthalamic nucleus deep brain stimulation on the final night or 2. Sleep scoring was determined manually by a consensus of 4 experts. Sleep macro-architecture was objectively quantified using the percentage, latency, and mean bout length of wake after sleep onset and on each stage of sleep (rapid eye movement and non-rapid eye movement stages 1, 2, 3).

resultsSleep was found to be highly disrupted in all nights. Sleep architecture on nights without stimulation was consistent with prior results in treatment naive patients with Parkinson's disease. No statistically significant difference was observed due to stimulation.

conclusionsThese objective measures suggest that 1 night of intermittent subthreshold stimulation appears insufficient to impact sleep macro-architecture. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease; URL: https://clinicaltrials.gov/ct2/show/NCT04620551; Identifier: NCT04620551. CITATION: Das R, Gliske SV, West LC, et al. Sleep macro-architecture in patients with Parkinson's disease does not change during the first night of neurostimulation in a pilot study.

Indexed as

Deep Brain StimulationParkinson DiseasePolysomnographyAgedFemaleHumansMaleMiddle AgedPilot ProjectsSleepSleep Wake Disordersdeep brain stimulationParkinson’s diseasepolysomnographysleep architecturesleep qualitysubthalamic nucleus

Identifiers

PMID38652493
PMCPMC11367722
OpenAlexW4395083041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.