Evidence map›Paper›PMID 38652421›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2024

Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson's disease.

Jin-Woo Park, Luis E Okamoto, Sung-Hwan Kim, Chan-Nyoung Lee, Kun Woo Park, Seol-Hee Baek, Joo Hye Sung, Namjoon Jeon, Seong-Beom Koh, Alfredo Gamboa and 4 more

Open access · greenAbstract read
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Redefining Non-Motor Symptoms in Parkinson's Disease.Journal of personalized medicine · 2025
    Review
  6. Comment to the article titled: sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Jin-Woo ParkDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Luis E OkamotoDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sung-Hwan KimDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Chan-Nyoung LeeDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Kun Woo ParkDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Seol-Hee BaekDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Joo Hye SungDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Namjoon JeonDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Seong-Beom KohDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea.
Alfredo GamboaDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Cyndya A ShibaoDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
André DiedrichDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Byung-Jo KimDepartment of Neurology, Korea University Anam Hospital, Korea University Medicine, #73, Goryeodae-Ro, Seongbuk-gu, Seoul, 02841, Korea. nukbj@korea.ac.kr.ORCID http://orcid.org/0000-0002-0445-7185
Italo BiaggioniDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Korea University · KRVanderbilt University Medical Center · USVanderbilt University · US

Funding

Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic HypotensionR01HL161095 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Italo Biaggioni, Luis Enrique Okamoto · 2022 to 2026
$3.2M
Automated Abdominal Binder for Orthostatic HypotensionR01HL144568 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OKAMOTO, LUIS ENRIQUE · 2020 to 2024
$2.7M
Autonomic Determinants of Postural Tachycardia SyndromeR01HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL142583NHLBI NIH HHS R01 HL144568NHLBI NIH HHS R01 HL161095NIH HHS R01 HL144568NIH HHS R01 HL161095
6 · The paper itself

Abstract

purposeThe specific characteristics of autonomic involvement in patients with early Parkinson's disease (PD) are unclear. This study aimed to evaluate the characteristics of autonomic dysfunction in drug-naïve patients with early-stage PD without orthostatic hypotension (OH) by analyzing Valsalva maneuver (VM) parameters.

methodsWe retrospectively analyzed drug-naïve patients without orthostatic hypotension (n = 61) and controls (n = 20). The patients were subcategorized into early PD (n = 35) and mid-PD (n = 26) groups on the basis of the Hoehn and Yahr staging. VM parameters, including changes in systolic blood pressure at late phase 2 (∆SBP

resultsIn the early PD group, ∆SBP

conclusionThe ∆BP

Indexed as

Autonomic Nervous System DiseasesBaroreflexParkinson DiseaseValsalva ManeuverAgedBlood PressureFemaleHumansMaleMiddle AgedRetrospective StudiesSympathetic Nervous SystemAutonomic dysfunctionParkinson’s diseaseSympathetic dysfunctionValsalva maneuver

Identifiers

PMID38652421
PMCPMC11652379
OpenAlexW4395043551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.