ArticleJournal of neurology2024
Gait asymmetry and symptom laterality in Parkinson's disease: two of a kind?
Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Gait asymmetry in Parkinson's disease - a systematic review and meta-analysis (AsymmGait-Parkinson study).Scientific reports · 2026Pooled it
- Stochastic resonance stimulation effect on stability during walking in people with Parkinson disease.International biomechanics · 2025Trial
- Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension.Movement disorders clinical practice · 2024Trial
- Motor-Derived Digital Biomarkers for Identifying Low-MoCA Status in People with Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Cross-Modal Synergy Representation of EMG and Joint Angular Acceleration During Gait in Parkinson's Disease Using NMF and Multimodal Matrix Factorization.Sensors (Basel, Switzerland) · 2026Article
- Video-based machine learning models for predicting deep brain stimulation outcomes in Parkinson's disease patients.NPJ Parkinson's disease · 2026Article
- Can neurologic music therapy make the difference when using immersive virtual reality in Parkinson disease motor training? Promising findings from a secondary analysis.Frontiers in rehabilitation sciences · 2026Article
- Characterising anticipatory postural adjustments in turning a comparison between older adults and people with Parkinson's disease.Scientific reports · 2025Article
- Pallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in a Rat Model of Parkinsonian.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Glymphatic dysfunction as a potential driver of cerebral iron deposition in Parkinson's disease.Brain communications · 2025Article
- Rhythmic auditory cues improve gait asymmetry during unobstructed walking in people with Parkinson's disease but have no effect on obstacle avoidance - AsymmGait-Parkinson study.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe laterality of motor symptoms is considered a key feature of Parkinson's disease (PD). Here, we investigated whether gait and turning asymmetry coincided with symptom laterality as determined by the MDS-UPRDS part III and whether it was increased compared to healthy controls (HC).
methodsWe analyzed the asymmetry of gait and turning with and without a cognitive dual task (DT) using motion capture systems and wearable sensors in 97 PD patients mostly from Hoehn & Yahr stage II and III and 36 age-matched HC. We also assessed motor symptom asymmetry using the bilateral sub-items of the MDS-UPDRS-III. Finally, we examined the strength of the association between gait asymmetry and symptom laterality.
resultsParticipants with PD had increased gait but not more turning asymmetry compared to HC (p < 0.05). Only 53.7% of patients had a shorter step length on the more affected body side as determined by the MDS-UPDRS-III. Also, 54% took more time and 29% more steps during turns toward the more affected side. The degree of asymmetry in the different domains did not correlate with each other and was not influenced by DT-load.
conclusionsWe found a striking mismatch between the side and the degree of asymmetry in different motor domains, i.e., in gait, turning, and distal symptom severity in individuals with PD. We speculate that motor execution in different body parts relies on different neural control mechanisms. Our findings warrant further investigation to understand the complexity of gait asymmetry in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.