Evidence map›Paper›PMID 38652045›Full record

ReviewThe Journal of clinical endocrinology and metabolism2024

Approach to the Patient: Concept and Application of Targeted Radiotherapy in the Paraganglioma Patient.

Karel Pacak, David Taieb, Frank I Lin, Abhishek Jha

Erratum issuedOpen access · greenAbstract readCase ReportsReview
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Phase II Study ofJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Trial
  2. Review
  3. Pheochromocytomas and Paragangliomas.Endocrinology and metabolism clinics of North America · 2026
    Review
  4. Approach to the Patient With Metastatic Pheochromocytoma and Paraganglioma.The Journal of clinical endocrinology and metabolism · 2025
    Article
  5. Review
  6. Urinary Dopamine Levels Can Predict the Avidity of Post-Therapy [Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  7. Endocrine oncology (Bristol, England) · 2025
    Article
  8. Article
  9. Article
  10. Case Series:Frontiers in endocrinology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-1109, USA.ORCID 0000-0002-3541-3767
David TaiebDepartment of Nuclear Medicine, Aix-Marseille University, La Timone University Hospital, 13385 Marseille, France.ORCID 0000-0002-0400-7600
Frank I LinMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0003-3539-1454
Abhishek JhaSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892-1109, USA.ORCID 0000-0002-1489-2471
National Institutes of Health · USAix-Marseille Université · FR

Funding

Phase 2 study of Lu-177-DOTATATE in inoperable paraganglioma - pheochromocytoaZIABC011789 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LIN, FRANK · 2017 to 2025
$1.9M
Diagnosis &Pathophysiology of PheochromocytomaZ01HD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2001 to 2008
$1.7M
Phase 12 study of Lu177-DOTATATE and olaparib in neuroendocrine tumorsZIABC011827 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LIN, FRANK · 2018 to 2025
$628k
Intramural NIH HHS Z01 HD008735K.P.National Institute of Child Health and Human DevelopmentNIH HHS Z1AHD008735
6 · The paper itself

Abstract

Paragangliomas can metastasize, posing potential challenges both in symptomatic management and disease control. Systemic targeted radiotherapies using 131I-MIBG and 177Lu-DOTATATE are a mainstay in the treatment of metastatic paragangliomas. This clinical scenario and discussion aim to enhance physicians' knowledge of the stepwise approach to treat these patients with paraganglioma-targeted radiotherapies. It comprehensively discusses current approaches to selecting paraganglioma patients for targeted radiotherapies and how to choose between the two radiotherapies based on specific patient and tumor characteristics, when either therapy is feasible, or one is superior to another. The safety, efficacy, toxicity profiles, and optimization of these radiotherapies are also discussed, along with other therapeutic options including radiotherapies, available for patients besides these two therapies. Perspectives in radiotherapies of paraganglioma patients are outlined since they hold promising approaches in the near future that can improve patient outcomes.

Indexed as

Paraganglioma3-IodobenzylguanidineAdrenal Gland NeoplasmsHumansOctreotideOrganometallic CompoundsRadiopharmaceuticals3-Iodobenzylguanidinelutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticals123/131I-metaiodobenzylguanidine18F-FDG18F-FDOPA68Ga-DOTATATELutathera®neuroendocrine tumorparagangliomapheochromocytomapositron emission tomographyradiotherapyscintigraphyα-emitter

Identifiers

PMID38652045
PMCPMC11319006
OpenAlexW4395022530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.