ArticleProceedings of the National Academy of Sciences of the United States of America1985
A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 100 citations in OpenAlex.
- Protein Sequencing with Single Amino Acid Resolution Discerns Peptides That Discriminate Tropomyosin Proteoforms.Journal of proteome research · 2025Article
- A novel pathogenic variant c.44A > G (p. Asp15Gly) inMolecular genetics and metabolism reports · 2025Article
- Getting the Entire Message: Progress in Isoform Sequencing.Frontiers in genetics · 2019Review
- Microfluidic isoform sequencing shows widespread splicing coordination in the human transcriptome.Genome research · 2018Article
- Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities.Clinical & experimental metastasis · 2002Article
- TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.The American journal of pathology · 2000Article
- Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression.The Journal of cell biology · 1993Article
- Induction of neuron-specific tropomyosin mRNAs by nerve growth factor is dependent on morphological differentiation.The Journal of cell biology · 1993Article
- Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing.Molecular and cellular biology · 1990Article
- In vitro splicing of mutually exclusive exons from the chicken beta-tropomyosin gene: role of the branch point location and very long pyrimidine stretch.The EMBO journal · 1990Article
- One-sided polymerase chain reaction: the amplification of cDNA.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Avian tropomyosin gene expression.Nucleic acids research · 1989Article
- Isolation and characterization of related cDNA clones encoding skeletal muscle beta-tropomyosin and a low-molecular-weight nonmuscle tropomyosin isoform.Molecular and cellular biology · 1989Article
- Mechanism of activation of the human trk oncogene.Molecular and cellular biology · 1989Article
- Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2.Molecular and cellular biology · 1988Article
- The Drosophila melanogaster tropomyosin II gene produces multiple proteins by use of alternative tissue-specific promoters and alternative splicing.Molecular and cellular biology · 1988Article
- Differential expression of a tropomyosin isoform in low- and high-metastatic Lewis lung carcinoma cells.Molecular and cellular biology · 1988Article
- Differential localization of tropomyosin isoforms in cultured nonmuscle cells.The Journal of cell biology · 1988Article
- Complete nucleotide sequence of the adult skeletal isoform of human skeletal muscle beta-tropomyosin.Nucleic acids research · 1988Article
- The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing.Molecular and cellular biology · 1988Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated a cDNA clone from a human fibroblast cDNA library that contains the entire protein-coding region of a 1.1-kilobase mRNA. This mRNA encodes a 284-amino acid tropomyosin, the primary structure of which most closely resembles smooth muscle tropomyosin. Thus, the expression of both 284-amino acid muscle-type and 247-amino acid non-muscle-type tropomyosins appears to be a normal feature of human non-muscle cells. We also present evidence to suggest that this cytoskeletal tropomyosin and a human skeletal muscle beta-tropomyosin are derived from a common structural gene by an alternative RNA splicing mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.