Evidence map›Paper›PMID 38651884›Full record

ArticleMicrobiology spectrum2024

Identification and characterization of a novel antifungal compound tubeimoside I targeting cell wall.

Qiannan Liu, Zhiqi Zhong, Shunxin Zheng, Yunzhuo Chu, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Qiannan Liu *Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.
Zhiqi Zhong *Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.
Shunxin ZhengDepartment of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.
Yunzhuo ChuDepartment of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
Norihiro SakamotoDivision of Food and Drug Evaluation Science, Kobe University Graduate School of Medicine, Kobe, Japan.
Takayoshi KunoDepartment of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.
Yue FangDepartment of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China.ORCID 0000-0002-0557-2118
China Medical University · CNKobe University · JPFirst Hospital of China Medical University · CN

Funding

Doctoral Start-up Foundation of Liaoning Province (Liaoning Provincial Doctoral Startup Foundation) 2020-BS-096Innovative Talents Support Program in University of Liaoning Provence in 2020MOST | National Key Research and Development Program of China (NKPs) 2021YFC2300402| Natural Science Foundation of Liaoning Province (Liaoning Natural Science Foundation) 2019-MS-384
6 · The paper itself

Abstract

Due to fungal diseases that threaten immunocompromised patients, along with the limited availability of antifungal agents, there is an urgent need for new antifungal compounds to treat fungal infections. Here, we aimed to identify potential antifungal drugs from natural products using the fission yeast IMPORTANCE: Fungal infections pose a serious threat to public health and have become an emerging crisis worldwide. The development of new antifungal agents is urgently needed. Here, we identified compound tubeimoside I (TBMS1) for the first time showing strong antifungal activity, and explored the underlying mechanisms of its antifungal action by using the model yeast

Indexed as

Antifungal AgentsCell WallSchizosaccharomycesMicrobial Sensitivity TestsSaponinsSchizosaccharomyces pombe ProteinsTriterpenesAntifungal AgentsSaponinsSchizosaccharomyces pombe ProteinsTriterpenestubeimoside Iantifungal activitycell wallSchizosaccharomyces pombetubeimoside I (TBMS1)

Identifiers

PMID38651884
PMCPMC11237440
OpenAlexW4395037763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.