Evidence map›Paper›PMID 38651694›Full record

Observational studyAmerican journal of physiology. Lung cellular and molecular physiology2024

Aberrant long-chain fatty acid metabolism associated with evolving systemic sclerosis-associated pulmonary arterial hypertension.

Julie C Coursen, Tijana Tuhy, Mario Naranjo, Adrianne Woods, Laura K Hummers, Ami A Shah, Karthik Suresh, Scott H Visovatti, Stephen C Mathai, Paul M Hassoun and 2 more

Open access · greenAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Julie C CoursenDivision of Hospital Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0009-0003-4847-6876
Tijana TuhyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Mario NaranjoDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, Pennsylvania, United States.ORCID 0000-0001-7584-2489
Adrianne WoodsDivision of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Laura K HummersDivision of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Ami A ShahDivision of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Karthik SureshDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0003-2920-0949
Scott H VisovattiDivision of Cardiology, Department of Medicine, The Ohio State University, Columbus, Ohio, United States.
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Paul M HassounDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0003-0601-4975
Rachel L DamicoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Catherine E SimpsonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0002-2388-5660
Johns Hopkins University · USOhio State University Hospital · USTemple University · US

Funding

Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Antony Rosen · 2016 to 2026
$8.9M
The role of xanthine oxidoreductase activity and altered metabolism in scleroderma-associated pulmonary arterial hypertensionK23HL153781 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIMPSON, CATHERINE · 2020 to 2024
$883k
Harnessing multivariate patient- and population-level disease trajectories to predict major clinical events in sclerodermaK24AR080217 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Ami Aalok Shah · 2022 to 2026
$847k
Novel Biomarkers of Right Ventricular Dysfunction in Pulmonary Arterial HypertensionF32HL159917 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NARANJO TOVAR, MARIO · 2022 to 2022
$57k
NHLBI NIH HHS F32 HL159917NHLBI NIH HHS K23 HL153781NIAMS NIH HHS K24 AR080217NIAMS NIH HHS P30 AR070254
6 · The paper itself

Abstract

We sought to investigate differential metabolism in patients with systemic sclerosis (SSc) who develop pulmonary arterial hypertension (PAH) versus those who do not, as a method of identifying potential disease biomarkers. In a nested case-control design, serum metabolites were assayed in SSc subjects who developed right heart catheterization-confirmed PAH (

Indexed as

Fatty AcidsPulmonary Arterial HypertensionScleroderma, SystemicAcetylcholinesteraseAgedArterial PressureBiological Specimen BanksEarly DiagnosisFemaleHumansLinoleic AcidLipid MetabolismLipidomicsLiquid Chromatography-Mass SpectrometryMaleMarylandAcetylcholinesteraseFatty AcidsLinoleic Acidmetabolism-omicspulmonary arterial hypertensionscleroderma

Identifiers

PMID38651694
PMCPMC11380974
OpenAlexW4395038990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.