ArticleJournal of the American Chemical Society2024
Photoredox Nucleophilic (Radio)fluorination of Alkoxyamines.
Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Programmable Functionalizations of Tetramethylpiperidine N-Oxyl (TEMPO)-Acrolein Linchpins Derived from Alkoxyallenes.Journal of the American Chemical Society · 2026Article
- Nitrosoarenes as Versatile Precursors forACS omega · 2026Article
- Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox-Mediated Radical Cross-Coupling.Angewandte Chemie (International ed. in English) · 2026Article
- Electrochemical Activation of α-Carbonyl Alkoxyamines for Direct Nucleophilic Substitution.Organic letters · 2026Article
- Distinct hydrogen atom transfer and radical capture reactivity of copper(iii) OH/F complexes enables site-selective C(spChemical science · 2026Article
- Iron-catalyzed three-component amino(radio)fluorination of alkenes to unprotected β-(radio)fluoroamines.Nature communications · 2025Article
- Cryogenic Organometallic Carbon-Fluoride Bond Functionalization with Broad Functional Group Tolerance.Journal of the American Chemical Society · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we report a photoredox nucleophilic (radio)fluorination using TEMPO-derived alkoxyamines, a class of substrates accessible in a single step from a diversity of readily available carboxylic acids, halides, alkenes, alcohols, aldehydes, boron reagents, and C-H bonds. This mild and versatile one-electron pathway affords radiolabeled aliphatic fluorides that are typically inaccessible applying conventional nucleophilic substitution technologies due to insufficient reactivity and competitive elimination. Automation of this photoredox process is also demonstrated with a user-friendly and commercially available photoredox flow reactor and radiosynthetic platform, therefore expediting access to labeled aliphatic fluorides in high molar activity (
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.