Evidence map›Paper›PMID 38651414›Full record

ReviewMedical sciences (Basel, Switzerland)2024

Efficacy of Sorafenib-Based Therapies for Non-Small Cell Lung Cancer.

Morgann Hendrixson, Yevgeniy Gladkiy, Anita Thyagarajan, Ravi P Sahu

Open access · goldAbstract readReview
In one paragraph

Review in Medical sciences (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Erbin Inhibited AngiogenesisCurrent medicinal chemistry · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Sorafenib-Drug Delivery Strategies in Primary Liver Cancer.Journal of functional biomaterials · 2025
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Morgann HendrixsonBoonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.ORCID 0009-0008-7271-4682
Yevgeniy GladkiyBoonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.
Anita ThyagarajanDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.
Ravi P SahuDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA.ORCID 0000-0003-3857-9073
Wright State University · US

Funding

Mechanisms of augmented UVB immunosuppressive responses by polyaromatic hydrocarbonsR21ES033806 · NIEHS · WRIGHT STATE UNIVERSITY · PI SAHU, RAVI PRAKASH · 2022 to 2024
$433k
NIEHS NIH HHS R21 ES033806
6 · The paper itself

Abstract

Lung cancer remains the leading cause of cancer-related deaths, with a poor prognosis. Of the two types, non-small cell lung cancer (NSCLC) is the major and most prevalent type and associated with low response rates to the current treatment options. Sorafenib, a multitargeted tyrosine kinase inhibitor used for various malignancies, gained attention for its potential efficacy in NSCLC. This review paper focuses on the findings of recent in vitro, in vivo, and clinical studies regarding the efficacy of sorafenib. Overall, sorafenib has shown definitive therapeutic potential in NSCLC cell lines, xenografts, and human subjects. Novel approaches to sorafenib delivery may improve its efficacy and should be the focus of further studies.

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsProtein Kinase InhibitorsSorafenibAnimalsHumansPhenylurea CompoundsAntineoplastic AgentsPhenylurea CompoundsProtein Kinase InhibitorsSorafenibcell signaling pathwaynon-small cell lung cancersorafenibtargeted therapy

Identifiers

PMID38651414
PMCPMC11036230
OpenAlexW4394578386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.