Evidence map›Paper›PMID 38650846›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2024

Disulfiram, an Anti-alcoholic Drug, Targets Macrophages and Attenuates Acute Rejection in Rat Lung Allografts.

Nobuyuki Yoshiyasu, Rei Matsuki, Masaaki Sato, Hirokazu Urushiyama, Etsuko Toda, Yasuhiro Terasaki, Masaki Suzuki, Aya Shinozaki-Ushiku, Yuya Terashima, Jun Nakajima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nobuyuki YoshiyasuDepartment of Thoracic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Rei MatsukiDepartment of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masaaki SatoDepartment of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Hirokazu UrushiyamaDepartment of Respiratory Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Etsuko TodaDepartment of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Yasuhiro TerasakiDepartment of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Masaki SuzukiDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Aya Shinozaki-UshikuDepartment of Pathology, The University of Tokyo Hospital, Tokyo, Japan.
Yuya TerashimaDivision of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Chiba, Japan.
Jun NakajimaDepartment of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
University of Tokyo Hospital · JPThe University of Tokyo · JPTokyo University of Science · JPNippon Medical School Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages contribute to post-transplant lung rejection. Disulfiram (DSF), an anti-alcoholic drug, has an anti-inflammatory effect and regulates macrophage chemotactic activity. Here, we investigated DSF efficacy in suppressing acute rejection post-lung transplantation. Male Lewis rats (280-300 g) received orthotopic left lung transplants from Fisher 344 rats (minor histocompatibility antigen-mismatched transplantation). DSF (0.75 mg/h) monotherapy or co-solvent only (50% hydroxypropyl-β-cyclodextrin) as control was subcutaneously administered for 7 days (n = 10/group). No post-transplant immunosuppressant was administered. Grades of acute rejection, infiltration of immune cells positive for CD68, CD3, or CD79a, and gene expression of monocyte chemoattractant protein and pro-inflammatory cytokines in the grafts were assessed 7 days post-transplantation. The DSF-treated group had significantly milder lymphocytic bronchiolitis than the control group. The infiltration levels of CD68

Indexed as

DisulfiramGraft RejectionLung TransplantationMacrophagesRats, Inbred F344Rats, Inbred LewAllograftsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticChemokine CCL2LungMaleRatsAntigens, CDAntigens, Differentiation, MyelomonocyticChemokine CCL2Disulfiramacute lung rejectiondisulfiramlung transplantationmacrophagerodent study

Identifiers

PMID38650846
PMCPMC11033352
OpenAlexW4394575267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.