Evidence map›Paper›PMID 38650743›Full record

ArticleAging brain2024

Estrogen's sex-specific effects on ischemic cell death and estrogen receptor mRNA expression in rat cortical organotypic explants.

Amanda L Trout, Christopher J McLouth, Jenne M Westberry, Tomoko Sengoku, Melinda E Wilson

Open access · goldAbstract read
In one paragraph

Article in Aging brain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Mitochondrial CaCell calcium · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda L TroutDepartment of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Christopher J McLouthDepartment of Neurology, University of Kentucky, Lexington, KY, 40536, USA.
Jenne M WestberryDepartment of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Tomoko SengokuDepartment of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Melinda E WilsonDepartment of Physiology, University of Kentucky, Lexington, KY 40536, USA.
University of Kentucky · US

Funding

Institutional Career Development CoreKL2TR001996 · NCATS · UNIVERSITY OF KENTUCKY · PI BUSH, MATTHEW LEE, KELLY, THOMAS H. · 2016 to 2025
$7.1M
NCATS NIH HHS KL2 TR001996
6 · The paper itself

Abstract

Estrogens, such as the biologically active 17-β estradiol (E2), regulate not only reproductive behaviors in adults, but also influence neurodevelopment and neuroprotection in both females and males. E2, contingent upon the timing and concentration of the therapy, is neuroprotective in female and male rodent models of stroke.

Indexed as

and EstrogenIschemiaStroke

Identifiers

PMID38650743
PMCPMC11033203
OpenAlexW4394867108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.