Evidence map›Paper›PMID 38650740›Full record

ArticleJournal of drug delivery science and technology2023

Chitosan-graphene quantum dot based active film as smart wound dressing.

Elisabete Regina Fernandes Ramos Ribeiro, Luana Barbosa Correa, Eduardo Ricci-Junior, Pedro Filho Noronha Souza, Clenilton Costa Dos Santos, Alan Silva de Menezes, Elaine Cruz Rosas, Prapanna Bhattarai, Mohamed F Attia, Lin Zhu and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of drug delivery science and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Elisabete Regina Fernandes Ramos RibeiroBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.
Luana Barbosa CorreaBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.
Eduardo Ricci-JuniorFederal University of Rio de Janeiro, School of Pharmacy, Galenic Development Laboratory (LADEG), Rio de Janeiro, 21941-170, Brazil.
Pedro Filho Noronha SouzaBiochemistry and Molecular Biology Department, Federal University of Ceará, CE, Brazil, Laboratory of Plant Defense Proteins, Ceará, 60451, Brazil.
Clenilton Costa Dos SantosFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil.
Alan Silva de MenezesFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil.
Elaine Cruz RosasNational Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Oswaldo Cruz Foundation, Rio de Janeiro, 21041361, Brazil.
Prapanna BhattaraiDepartment of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA.
Mohamed F AttiaCenter for Nanotechnology in Drug Delivery and Division of Pharmaco-engineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Lin ZhuDepartment of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, 77843, USA.
Luciana Magalhães Rebelo AlencarFederal University of Maranhão, Department of Physics, Laboratory of Biophysics and Nanosystems, Campus Bacanga, São Luís, Maranháo, 65080-805, Brazil.
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, 21941906, Brazil.
Universidade Federal do Maranhão · BRNuclear Engineering Institute · BRTexas A&M University · USFundação Oswaldo Cruz · BRUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal do Ceará · BRUniversidade Federal do Rio de Janeiro · BRUniversity of North Carolina at Chapel Hill · US

Funding

Improving tumor specificity and overcoming drug resistance of proteasome inhibitors by a dual-targeted drug delivery systemR15CA213103 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ZHU, LIN · 2018 to 2018
$444k
NCI NIH HHS R15 CA213103
6 · The paper itself

Abstract

Graphene quantum dots (GQDs), are biocompatible materials, with mechanical strength and stability. Chitosan, has antibacterial and anti-inflammatory properties, and biocompatibility. Wound healing is a challenging process especially in chronic diseases and infection. In this study, films consisting of chitosan and graphene quantum dots were developed for application in infected wounds. The chitosan-graphene films were prepared in the acidic solution followed by slow solvent evaporation and drying. The chitosan-graphene films were characterized by the scanning electron microscopy, x-ray diffraction, atomic force microscopy, Raman spectroscopy and thermogravimetric analysis. The films' was evaluated by the wound healing assays, hemolytic potential, and nitrite production, cytokine production and swelling potential. The obtained films were flexible and well-structured, promoting cell migration, greater antibacterial activity, lower hemolytic activity, and maintaining wound moisture. Our data suggested that the use of graphene quantum dot-containing chitosan films would be an efficient and promising way in combating wounds.

Indexed as

ChitosanCicatrizationGraphene quantum dotsInflammationWound dressing

Identifiers

PMID38650740
PMCPMC11034917
OpenAlexW4313442900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.