Evidence map›Paper›PMID 38650654›Full record

ArticlePeerJ2024

Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma.

Yan Chen, Xiuhong Weng, Chuanjie Zhang, Simin Wang, Xuechen Wu, Bo Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yan Chen *Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiuhong Weng *Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Chuanjie ZhangDepartment of Children Health Care, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Simin WangDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xuechen WuDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Bo ChengDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Zhongnan Hospital of Wuhan University · CNWuhan University · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting tumor angiogenesis is an important approach in advanced tumor therapy. Here we investigated the effect of the suppressor of variegation 3-9 homolog 1 (SUV39H1) on tumor angiogenesis in oral squamous cell carcinoma (OSCC). The GEPIA database was used to analyze the expression of SUV39H1 in various cancer tissues. The expression of SUV39H1 in OSCC was detected by immunohistochemistry, and the correlation between SUV39H1 and Notch1 and microvascular density (MVD) was analyzed. The effect of SUV39H1 inhibition on OSCC was investigated

Indexed as

Carcinoma, Squamous CellMethyltransferasesMouth NeoplasmsNeovascularization, PathologicReceptor, Notch1Repressor ProteinsAngiogenesisAnimalsCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMiceMethyltransferasesNOTCH1 protein, humanReceptor, Notch1Repressor ProteinsSUV39H1 protein, humanNotch1Oral squamous cell carcinomaSUV39H1Tumor angiogenesis

Identifiers

PMID38650654
PMCPMC11034493
OpenAlexW4394961709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.