Evidence map›Paper›PMID 38650595›Full record

ArticleOrgans-on-a-chip2021

Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure.

Jonathan R Soucy, Gabriel Burchett, Ryan Brady, Kyla Nichols, David T Breault, Abigail N Koppes, Ryan A Koppes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organs-on-a-chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jonathan R SoucyChemical Engineering, Northeastern University, Boston, MA, USA.
Gabriel BurchettChemical Engineering, Northeastern University, Boston, MA, USA.
Ryan BradyChemical Engineering, Northeastern University, Boston, MA, USA.
Kyla NicholsChemical Engineering, Northeastern University, Boston, MA, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Center for Life Sciences, Boston, MA, USA.
Abigail N KoppesChemical Engineering, Northeastern University, Boston, MA, USA.
Ryan A KoppesChemical Engineering, Northeastern University, Boston, MA, USA.
Northeastern University · USBoston Children's Hospital · US

Funding

Engineering a Humanized Gut-Enteric-AxisR21EB025395 · NIBIB · NORTHEASTERN UNIVERSITY · PI KOPPES, ABIGAIL NELSON, KOPPES, RYAN ALAN · 2018 to 2020
$628k
American Heart Association-American Stroke Association 19IPLOI34760604American Heart Association-American Stroke Association 19PRE34430181NIBIB NIH HHS R21 EB025395
6 · The paper itself

Abstract

Transition to extrauterine life results in a surge of catecholamines necessary for increased cardiovascular, respiratory, and metabolic activity. Mechanisms mediating adrenomedullary catecholamine release are poorly understood. Important mechanistic insight is provided by newborns delivered by cesarean section or subjected to prenatal nicotine or opioid exposure, demonstrating impaired release of adrenomedullary catecholamines. To investigate mechanisms regulating adrenomedullary innervation, we developed compartmentalized 3D microphysiological systems (MPS) by exploiting

Indexed as

Adrenal medullaCatecholaminesMicrophysiological systemsNeural engineeringTissue engineering

Identifiers

PMID38650595
PMCPMC11034938
OpenAlexW3210365653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.