Evidence map›Paper›PMID 38650546›Full record

ReviewCancer medicine2024

Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view.

Sandra Nuyts, Heleen Bollen, Avrahram Eisbruch, Primoz Strojan, William M Mendenhall, Sweet Ping Ng, Alfio Ferlito

Abstract readReview
In one paragraph

Review in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sandra NuytsLaboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-5540-4796
Heleen BollenLaboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, Leuven, Belgium.
Avrahram EisbruchDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Primoz StrojanDepartment of Radiation Oncology Institute of Oncology, University of Ljubljana, Ljubljana, Slovenia.
William M MendenhallDepartment of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA.
Sweet Ping NgDepartment of Radiation Oncology, Olivia Newton-John Cancer and Wellness Centre, Austin Health, Melbourne, Australia.
Alfio FerlitoCoordinator International Head and Neck Scientific Group, Udine, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with head and neck cancer (HNC) may experience substantial anatomical changes during the course of radiotherapy treatment. The implementation of adaptive radiotherapy (ART) proves effective in managing the consequent impact on the planned dose distribution.

methodsThis narrative literature review comprehensively discusses the diverse strategies of ART in HNC and the documented dosimetric and clinical advantages associated with these approaches, while also addressing the current challenges for integration of ART into clinical practice. RESULTS AND

conclusionAlthough based on mainly non-randomized and retrospective trials, there is accumulating evidence that ART has the potential to reduce toxicity and improve quality of life and tumor control in HNC patients treated with RT. However, several questions remain regarding accurate patient selection, the ideal frequency and timing of replanning, and the appropriate way for image registration and dose calculation. Well-designed randomized prospective trials, with a predetermined protocol for both image registration and dose summation, are urgently needed to further investigate the dosimetric and clinical benefits of ART.

Indexed as

Head and Neck NeoplasmsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedHumansQuality of LifeRadiation OncologistsRadiotherapy, Image-GuidedRadiotherapy, Intensity-Modulatedadaptive radiotherapyhead and neck cancerreview

Identifiers

PMID38650546
PMCPMC11036082

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.