ArticleBioresources and bioprocessing2021
Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation.
Article in Bioresources and bioprocessing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Transcriptomic Insights into Metabolic Reprogramming and Exopolysaccharide Synthesis inMarine drugs · 2026Article
- Comparative analysis of two Porphyridium species for phycobiliprotein and polysaccharide production under different photoperiods.Bioresources and bioprocessing · 2025Article
- Sulfated Exopolysaccharides fromF1000Research · 2025Review
- Enhanced growth and metabolite production from a novel strain ofBioengineered · 2024Article
- Inorganic salt starvation improves the polysaccharide production and COBioprocess and biosystems engineering · 2024Article
- Maximizing Polysaccharides and Phycoerythrin inMarine drugs · 2024Article
- Reconstruction of Long-Chain Polyunsaturated Acid Synthesis Pathways in Marine Red MicroalgaMarine drugs · 2024Article
- Current advances for omics-guided process optimization of microbial manufacturing.Bioresources and bioprocessing · 2023Review
- Circadian rhythm promotes the biomass and amylose hyperaccumulation by mixotrophic cultivation of marine microalga Platymonas helgolandica.Biotechnology for biofuels and bioproducts · 2022Article
- From formic acid to single-cell protein: genome-scale revealing the metabolic network of Paracoccus communis MA5.Bioresources and bioprocessing · 2022Article
- Cell adaptation of the extremophilic red microalgaFrontiers in plant science · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Porphyridium purpureum is a mesophilic, unicellular red alga rich in phycoerythrin, sulfate polysaccharides, and polyunsaturated fatty acids. Nitrogen deficiency inhibited the growth of P. purpureum and resulted in yellowing of the cells and thickening of the extracellular viscousness sheath. Under nitrogen stress, the contents of total lipids and exopolysaccharides in P. purpureum were increased by 65.2% and 188.0%, respectively. We demonstrate that the immediate response of P. purpureum to nitrogen deficiency is mediated by carbon flow to polysaccharide synthesis, while the synthesis of lipids is enhanced as a permanent energy storage substance at the later stage. Based on transcriptome annotation information, we elucidate the synthesis pathway of polysaccharides from P. purpureum from the perspective of glycosyl-donor interconversion, and demonstrate that the n-6 pathway is the main synthesis pathway of polyunsaturated fatty acids. This study not only provides a production strategy for polysaccharides and fatty acids by single-celled marine red algae P. purpureum, but also provides targets for further genetic modification.
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